Linked Life Data

9030222

Source:http://linkedlifedata.com/resource/pubmed/id/9030222

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1997-3-14
pubmed:abstractText
Because a strong correlation exists between the potency of general anesthetics and their ability to dissolve in oil, a lipophilic site of action is often assumed. We show here that a lipophilic molecule may preferentially target less lipophilic sites after interaction with a membrane takes place. Xenon, a chemically inert and structureless general anesthetic, was chosen as an unbiased molecular probe for assessment of its dynamic distribution. Site-selective intermolecular 129Xe-[1H] nuclear Overhauser effects were used to measure the specific interaction between xenon and protons in different regions in a phosphatidylcholine lipid membrane. It was evident that xenon-membrane interaction was directed toward the amphiphilic head region, with significant involvement of interfacial water, despite xenon's apolar and highly lipophilic nature in the gas phase. This result may suggest the importance of amphiphilicity in association with anesthetic action.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0006-3002
pubmed:author
pubmed:issnType
Print
pubmed:day
14
pubmed:volume
1323
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
154-62
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
Amphiphilic sites for general anesthetic action? Evidence from 129Xe-[1H] intermolecular nuclear Overhauser effects.
pubmed:affiliation
Department of Anesthesiology and Critical Care Medicine, University of Pittsburgh, PA 15261, USA. xu2+@pitt.edu
pubmed:publicationType
Journal Article, In Vitro, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't