Linked Life Data

9029350

Source:http://linkedlifedata.com/resource/pubmed/id/9029350

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
1997-4-10
pubmed:abstractText
During fermentation, lactic acid bacteria may be able to release components that possess immunomodulatory activity. This activity was investigated in several culture supernatants arising from lactic acid bacteria cultured in a medium composed primarily of UF permeate of bovine milk; beta-CN was added as the sole protein source. Only a Lactobacillus helveticus supernatant allowed the modulation (both suppression and enhancement) of lymphocyte proliferation in vitro on human peripheral blood lymphocytes, but L. helveticus did not modulate the cytotoxic activity of natural killer cells or of lymphokine-activated killer cells. The addition of different quantities of culture supernatant to cultures of human mononuclear cells, stimulated by the mitogen concanavalin A, significantly increased the production of interferon-gamma and decreased the production of interleukin-2 and the expression of the alpha-chain of the interleukin-2 receptor (p55), all of which appear to be correlated with the decrease in lymphocyte proliferation. Our results suggest that the culture supernatant activity might be related to interaction with monocyte-macrophage and T helper cells, especially Th1-like cells.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0022-0302
pubmed:author
pubmed:issnType
Print
pubmed:volume
79
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2112-20
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
Immunomodulatory activity of beta-casein permeate medium fermented by lactic acid bacteria.
pubmed:affiliation
Laboratoire de Recherches de Technologie Laitière, Institut National de la Recherche Agronomique, Rennes, France.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't