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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
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pubmed:dateCreated |
1997-3-5
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pubmed:abstractText |
We have previously reported the cloning of a novel cytokine, IFN-gamma-inducing factor (IGIF), which shared some biologic activities with IL-12. In this study, we analyzed the effects of murine IGIF on the activation of T cells, and compared the effects with those of IL-12. IGIF alone had no effect on the activation of T cell lines or Th1 clones, while IGIF increased the IFN-gamma production by antigen-stimulated T cell lines, but had no effect on IL-4 or IL-10 production. As reported with IL-12, IGIF served as a costimulatory factor for Th1 clones stimulated with Ag on B cell APC, immobilized anti-CD3, Con A, or IL-2 to augment IFN-gamma production and to induce IL-2R alpha-chain expression and proliferation of the Th1 clones, whereas IGIF had little or no effect on the IL-4 production and proliferation of Th2 clones stimulated with anti-CD3 or Ag. However, IGIF synergized with IL-12 to further augment the IFN-gamma production of the Th1 clones. Even in the presence of saturated amounts of IL-12, IGIF still augmented the IFN-gamma production and proliferation and enhanced the IL-2R alpha-chain expression of the Th1 clones. In contrast with IL-12, IGIF induced IL-2 production by Ag- or anti-CD3-stimulated Th1 clones. These two findings indicate that IGIF and IL-12 are utilizing different signal transduction pathways. We also found that IGIF as well as IL-12 was endogenously released through interaction between Th1 cells and spleen cell APC in the presence of specific Ag, and that it regulated IFN-gamma production. These results further suggest that IGIF may act as an immunoregulatory factor in the immune response.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon Inducers,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-12,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-18,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-2,
http://linkedlifedata.com/resource/pubmed/chemical/Ovalbumin,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Interleukin-2
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0022-1767
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
158
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1541-50
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:9029088-Animals,
pubmed-meshheading:9029088-Cell Line,
pubmed-meshheading:9029088-Clone Cells,
pubmed-meshheading:9029088-Cytokines,
pubmed-meshheading:9029088-Dose-Response Relationship, Immunologic,
pubmed-meshheading:9029088-Drug Synergism,
pubmed-meshheading:9029088-Female,
pubmed-meshheading:9029088-Interferon Inducers,
pubmed-meshheading:9029088-Interferon-gamma,
pubmed-meshheading:9029088-Interleukin-12,
pubmed-meshheading:9029088-Interleukin-18,
pubmed-meshheading:9029088-Interleukin-2,
pubmed-meshheading:9029088-Lymphocyte Activation,
pubmed-meshheading:9029088-Mice,
pubmed-meshheading:9029088-Mice, Inbred BALB C,
pubmed-meshheading:9029088-Mice, Inbred C3H,
pubmed-meshheading:9029088-Mice, Inbred C57BL,
pubmed-meshheading:9029088-Ovalbumin,
pubmed-meshheading:9029088-Receptors, Interleukin-2,
pubmed-meshheading:9029088-Th1 Cells,
pubmed-meshheading:9029088-Th2 Cells
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pubmed:year |
1997
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pubmed:articleTitle |
IFN-gamma-inducing factor (IGIF) is a costimulatory factor on the activation of Th1 but not Th2 cells and exerts its effect independently of IL-12.
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pubmed:affiliation |
Fujisaki Institute, Hayashibara Biochemical Laboratories, Inc., Okayama, Japan.
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pubmed:publicationType |
Journal Article,
Comparative Study
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