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rdf:type |
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lifeskim:mentions |
umls-concept:C0033684,
umls-concept:C0040557,
umls-concept:C0332597,
umls-concept:C1145667,
umls-concept:C1166650,
umls-concept:C1335222,
umls-concept:C1514562,
umls-concept:C1549781,
umls-concept:C1880389,
umls-concept:C1883204,
umls-concept:C1883221,
umls-concept:C2752522
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pubmed:issue |
2
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|
pubmed:dateCreated |
1997-6-3
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pubmed:databankReference |
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pubmed:abstractText |
The cDNA encoding the Toxoplasma gondii microneme protein MIC1 and the corresponding gene have been cloned and sequenced. The MIC1 gene contains three introns. The cDNA encodes a 456 amino acid (aa) sequence, with a typical signal sequence and no other trans-membrane domain. The protein contains a tandemly duplicated domain with conservation of cysteines and presents distant homology with the Plasmodium sp. microneme protein TRAP-SSP2. The MIC1 protein from tachyzoite lysates and a PMAL recombinant expressing the N-terminal duplicated domain of the protein bound to the surface of putative host cells, suggesting a possible involvement of MIC1 in host cell binding/recognition.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0166-6851
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
20
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pubmed:volume |
83
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
201-10
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9027753-Amino Acid Sequence,
pubmed-meshheading:9027753-Animals,
pubmed-meshheading:9027753-Base Sequence,
pubmed-meshheading:9027753-Cell Adhesion,
pubmed-meshheading:9027753-Cell Adhesion Molecules,
pubmed-meshheading:9027753-Cercopithecus aethiops,
pubmed-meshheading:9027753-Cloning, Molecular,
pubmed-meshheading:9027753-DNA, Complementary,
pubmed-meshheading:9027753-Genes, Protozoan,
pubmed-meshheading:9027753-Introns,
pubmed-meshheading:9027753-Molecular Sequence Data,
pubmed-meshheading:9027753-Molecular Weight,
pubmed-meshheading:9027753-Protein Binding,
pubmed-meshheading:9027753-Protozoan Proteins,
pubmed-meshheading:9027753-Recombinant Fusion Proteins,
pubmed-meshheading:9027753-Sequence Analysis, DNA,
pubmed-meshheading:9027753-Sequence Homology, Amino Acid,
pubmed-meshheading:9027753-Toxoplasma,
pubmed-meshheading:9027753-Vero Cells
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pubmed:year |
1996
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pubmed:articleTitle |
The MIC1 microneme protein of Toxoplasma gondii contains a duplicated receptor-like domain and binds to host cell surface.
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pubmed:affiliation |
INSERM U42, Villeneuve d' Ascq, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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