Linked Life Data

9026533

Source:http://linkedlifedata.com/resource/pubmed/id/9026533

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1997-2-20
pubmed:abstractText
The phase properties and structural characteristics of stratum corneum (SC) lipid lamellae have been a subject of considerable interest. To clarify the individual role of the stratum corneum constituent lipids, such as ceramides, free fatty acids, and cholesterol, we investigated the thermotropic properties and aggregation structures of a pseudo-ceramide/stearic acid (1/1 mole ratio)-cholesterol system, which is a simplified model for the natural lipids. Differential scanning calorimetry (DSC) detected decreases of melting entropies (delta Sm) by the incorporation of cholesterol into both anhydrous and hydrated equimolar mixture of pseudo-ceramide (SLE) and stearic acid. Moreover, there was a linear relationship between the cholesterol content and the melting entropies in the region of 0-33 mol% cholesterol for both the anhydrous and hydrate lipids. In addition, as the concentration of cholesterol increased, a liquid lateral packing (4.5 A) appeared in the wide-angle X-ray diffraction and the intensity of a hexagonal packing (4.15 A) decreased. The results from the present study strongly follow the idea that cholesterol can regulate the mobility of hydrocarbon chains of the natural stratum corneum lipid bilayer, which is primarily responsible for the barrier properties.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0022-2275
pubmed:author
pubmed:issnType
Print
pubmed:volume
37
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
361-7
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
Phase behavior of artificial stratum corneum lipids containing a synthetic pseudo-ceramide: a study of the function of cholesterol.
pubmed:affiliation
Wakayama Research Laboratories, Kao Corporation, Japan.
pubmed:publicationType
Journal Article