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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1997-3-7
|
| pubmed:abstractText |
Medical devices emitting pulsed electric and electromagnetic fields have been found to be effective for a number of clinical applications including stimulation of bone and tissue growth. To determine whether pulsed fields of the type used in these clinical applications present a mutagenic hazard, electric and electromagnetic fields at two exposure levels were tested in the Ames test, CHO cell chromosomal aberration assay, BALB/3T3 cell transformation assay and unscheduled DNA synthesis assay in primary rat hepatocytes. For both field types, initial and independent repeat studies were performed for each assay at both clinical and supra clinical doses. In all assays, the results show a lack of cytotoxic, transforming and mutagenic activity. The data suggest that pulsed electric and electromagnetic fields of the type and dose levels used in bone growth stimulation lack mutagenic and transforming activity.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
0027-5107
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
15
|
| pubmed:volume |
388
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
45-57
|
| pubmed:dateRevised |
2005-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:9025791-3T3 Cells,
pubmed-meshheading:9025791-Animals,
pubmed-meshheading:9025791-CHO Cells,
pubmed-meshheading:9025791-Cell Transformation, Neoplastic,
pubmed-meshheading:9025791-Cells, Cultured,
pubmed-meshheading:9025791-Chromosome Aberrations,
pubmed-meshheading:9025791-Cricetinae,
pubmed-meshheading:9025791-DNA Replication,
pubmed-meshheading:9025791-Electricity,
pubmed-meshheading:9025791-Electromagnetic Fields,
pubmed-meshheading:9025791-Escherichia coli,
pubmed-meshheading:9025791-Liver,
pubmed-meshheading:9025791-Male,
pubmed-meshheading:9025791-Mice,
pubmed-meshheading:9025791-Mutagenesis,
pubmed-meshheading:9025791-Mutagenicity Tests,
pubmed-meshheading:9025791-Rats,
pubmed-meshheading:9025791-Rats, Sprague-Dawley,
pubmed-meshheading:9025791-Salmonella typhimurium
|
| pubmed:year |
1997
|
| pubmed:articleTitle |
Evaluation of potential genotoxicity of pulsed electric and electromagnetic fields used for bone growth stimulation.
|
| pubmed:affiliation |
Genetic Toxicology Division, Microbiological Associates, Inc., Rockville, MD 20850, USA. djacobson-kram@microbio.com
|
| pubmed:publicationType |
Journal Article
|