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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1997-6-23
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pubmed:abstractText |
The serpent (srp) gene, also known as ABF, codes for a GATA-like transcription factor and is involved in the transcription activation of Adh in the larval fat body or adipose tissue. Here, we describe the tissue-specific distribution of SRP protein in various stages of embryonic development and describe srp's role in early fat-cell development. SRP protein was detected in the progenitor fat-body cells and is present in the developing fat-body cells and in the mature embryonic fat body. An analysis of srp embryos revealed a gradual loss of precursor fat cells that is likely due to apoptosis. Within the fat-cell lineage, srp is necessary for progression through early stages of fat-cell development and may be involved in the transactivation of genes necessary for fat-cell differentiation.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0925-4773
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
60
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
197-205
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9025072-Animals,
pubmed-meshheading:9025072-Apoptosis,
pubmed-meshheading:9025072-DNA-Binding Proteins,
pubmed-meshheading:9025072-Drosophila,
pubmed-meshheading:9025072-Drosophila Proteins,
pubmed-meshheading:9025072-Embryo, Nonmammalian,
pubmed-meshheading:9025072-Fat Body,
pubmed-meshheading:9025072-GATA Transcription Factors,
pubmed-meshheading:9025072-Hemocytes,
pubmed-meshheading:9025072-In Situ Hybridization,
pubmed-meshheading:9025072-Mutation,
pubmed-meshheading:9025072-Time Factors,
pubmed-meshheading:9025072-Tissue Distribution,
pubmed-meshheading:9025072-Transcription Factors
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pubmed:year |
1996
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pubmed:articleTitle |
The serpent gene is necessary for progression through the early stages of fat-body development.
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pubmed:affiliation |
Department of Biological Sciences, University of Nevada at Las Vegas 89154-4004, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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