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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2-3
|
| pubmed:dateCreated |
1997-5-12
|
| pubmed:abstractText |
Numerous studies have dealt with occurrence of dendritic cells in various nonlymphoid organs such as kidney, liver or heart, whereas lymphocyte patterns in these organs have not been analyzed in detail. In the present study, leukocytes were quantified as cells/mm2 in the perivascular, interstitial and parenchymal tissue sections of normal heart. We measured an overall mean leukocyte count in normal heart tissue of 17.0 +/- 2.7 CD45+ leukocytes/mm2, 9.1 +/- 1.8 thereof being CD4+ T-helper cells (Th). By comparison, CD8+ T-cytotoxic/suppressor cells (Ts) and CD14+ macrophages each accounted for only approximately 2.5 cells/mm2, and CD20+ B cells for only 1.3 cells/mm2. These T cells were further characterized as either CD45RA+ naive T cells or as CD45RO+ memory T cells. Segmentation of the tissue as defined in Section 2 yielded an ascending number of CD45RO+ memory T cells from perivascular (0.4 +/- 0.2 cells/mm2) through parenchymal (12.8 +/- 3.0 cells/mm2) to interstitial (21.0 +/- 5.3/mm2). By contrast, the number of CD45RA+ and Leu-8+ cells decreased from perivascular to parenchymal. Peripheral T cells showed a reverse pattern of CD45RA/CD45RO antigen expression. Only approximately 3% of T cells expressed activation markers IL-2R and IL7R. Our data demonstrate that the majority of T cells in normal heart tissue are resting memory tissue T cells and are not contaminating T cells from the peripheral blood. The increase in CD45RO+ cells from perivascular to parenchymal with a corresponding decrease in CD45RO+ and Leu-8+ heart-tissue T cells argues in favor of T-cell traffic in normal heart tissue.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD14,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD20,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD45,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/Cell Adhesion Molecules,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-7,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Interleukin-2
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
0165-2478
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
53
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
63-7
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:9024980-Antigens, CD,
pubmed-meshheading:9024980-Antigens, CD14,
pubmed-meshheading:9024980-Antigens, CD20,
pubmed-meshheading:9024980-Antigens, CD45,
pubmed-meshheading:9024980-Antigens, Neoplasm,
pubmed-meshheading:9024980-B-Lymphocytes,
pubmed-meshheading:9024980-CD4-Positive T-Lymphocytes,
pubmed-meshheading:9024980-CD8-Positive T-Lymphocytes,
pubmed-meshheading:9024980-Cell Adhesion Molecules,
pubmed-meshheading:9024980-Heart,
pubmed-meshheading:9024980-Heart Transplantation,
pubmed-meshheading:9024980-Humans,
pubmed-meshheading:9024980-Immunologic Memory,
pubmed-meshheading:9024980-Interleukin-7,
pubmed-meshheading:9024980-Leukocyte Count,
pubmed-meshheading:9024980-Macrophages,
pubmed-meshheading:9024980-Membrane Glycoproteins,
pubmed-meshheading:9024980-Myocardium,
pubmed-meshheading:9024980-Receptors, Interleukin-2,
pubmed-meshheading:9024980-T-Lymphocyte Subsets,
pubmed-meshheading:9024980-T-Lymphocytes
|
| pubmed:year |
1996
|
| pubmed:articleTitle |
Are T cells from healthy heart really only passengers? Characterization of cardiac tissue T cells.
|
| pubmed:affiliation |
Dept. of Cardiac Surgery, aö Kh St. Pölten, Austria.
|
| pubmed:publicationType |
Journal Article
|