Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1997-4-29
pubmed:abstractText
Hereditary factors confer susceptibility to alcohol dependence. Alcohol mediates its reinforcing effects by enhancing dopamine activity in the mesolimbic dopamine system. The role of the dopamine transporter in terminating dopaminergic activity in synaptic neurotransmission suggests that variants of the dopamine transporter gene (DAT1) might contribute to individual differences in vulnerability to addictive behavior. Our population-based association study investigated whether variants of DAT1 confer susceptibility to alcohol dependence in 293 alcoholics and clinically more homogeneous subgroups formed by: positive family history, early age-at-onset, delirium, withdrawal seizures, antisocial tendencies, type 1 and 2 alcoholics. Analyzing a VNTR polymorphism in the 3' untranslated region of DAT1, we found a significantly increased prevalence of the nine-repeat allele in 93 alcoholics displaying withdrawal seizures or delirium, compared with 93 ethnically matched nonalcoholic controls (p = 0.003; OR = 2.44; 95% confidence interval: 1.35-4.43). Our data provide evidence that a major genetic determinant of DAT1 influences vulnerability to severe alcohol withdrawal symptoms.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0006-3223
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
41
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
299-304
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:9024952-Adult, pubmed-meshheading:9024952-Alcohol Withdrawal Delirium, pubmed-meshheading:9024952-Alcoholism, pubmed-meshheading:9024952-Alleles, pubmed-meshheading:9024952-Carrier Proteins, pubmed-meshheading:9024952-Dopamine Plasma Membrane Transport Proteins, pubmed-meshheading:9024952-Female, pubmed-meshheading:9024952-Genetics, Population, pubmed-meshheading:9024952-Genotype, pubmed-meshheading:9024952-Humans, pubmed-meshheading:9024952-Male, pubmed-meshheading:9024952-Membrane Glycoproteins, pubmed-meshheading:9024952-Membrane Transport Proteins, pubmed-meshheading:9024952-Middle Aged, pubmed-meshheading:9024952-Nerve Tissue Proteins, pubmed-meshheading:9024952-Phenotype, pubmed-meshheading:9024952-Polymerase Chain Reaction, pubmed-meshheading:9024952-Polymorphism, Genetic, pubmed-meshheading:9024952-Seizures, pubmed-meshheading:9024952-Substance Withdrawal Syndrome
pubmed:year
1997
pubmed:articleTitle
Allelic association of a dopamine transporter gene polymorphism in alcohol dependence with withdrawal seizures or delirium.
pubmed:affiliation
Department of Psychiatry, University Hospital Benjamin Franklin, Free University of Berlin, Germany.
pubmed:publicationType
Journal Article, Clinical Trial, Research Support, Non-U.S. Gov't