Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1997-3-4
pubmed:abstractText
We performed this study to evaluate the effects of changing the level of nitric oxide (NO) on disruption of the blood-brain barrier (BBB) by hyperosmolar mannitol. Under isoflurane anesthesia, control rats (control group, n = 6) were given infusions with 25% mannitol into the internal carotid artery before measuring the transfer coefficient (Ki) of 14C-alpha-aminoisobutyric acid (14C-AIB). In the CAS group (n = 6), [3-(cis-2,6-dimethyl piperidino)-sydnonimine] (CAS 754), a NO donor, was injected to decrease the mean arterial pressure (MAP) to 55 mm Hg and in the L-NAME group (n = 6), NG-nitro-L-arginine methyl ester (L-NAME), a NO synthase inhibitor, was injected before administering mannitol. In additional control animals (control + P group, n = 6) and additional CAS 754-treated animals (CAS + P group, n = 6), phenylephrine was infused to keep MAP at 130 mm Hg during the experimental period. In the control group, with mannitol injection, the Ki of the ipsilateral cortex (IC) where mannitol was injected increased to 4.3 times that of the contralateral cortex (CC) (17.2 +/- 2.9 vs 4.0 +/- 2.6 microliters.g-1.min.1). Without blood pressure control, the Ki of the IC of the CAS group (7.0 +/- 4.5) was lower and that of the L-NAME group (26.2 +/- 12.7) was higher than that of the control animals. At the same MAP, the Ki of the IC of the CAS + P group (9.6 +/- 3.1) was significantly lower than that of the control + P group (21.3 +/- 14.5) or that of the L-NAME group. There was no significant difference in the Ki of the IC between the control + P and the L-NAME groups. In conclusion, L-NAME worsened BBB disruption induced by hyperosmolar solution, which may be due to the pressure effect of L-NAME. CAS 754 was effective in attenuating disruption of the BBB caused by hyperosmolar mannitol. This effect is apparently not due to decreased MAP.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/3-(cis-2,6-dimethylpiperidino)sydnon..., http://linkedlifedata.com/resource/pubmed/chemical/Aminobutyric Acids, http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors, http://linkedlifedata.com/resource/pubmed/chemical/Mannitol, http://linkedlifedata.com/resource/pubmed/chemical/NG-Nitroarginine Methyl Ester, http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide, http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase, http://linkedlifedata.com/resource/pubmed/chemical/Phenylephrine, http://linkedlifedata.com/resource/pubmed/chemical/Sydnones, http://linkedlifedata.com/resource/pubmed/chemical/Vasoconstrictor Agents, http://linkedlifedata.com/resource/pubmed/chemical/Vasodilator Agents, http://linkedlifedata.com/resource/pubmed/chemical/butyrine
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0003-2999
pubmed:author
pubmed:issnType
Print
pubmed:volume
84
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
370-5
pubmed:dateRevised
2005-11-17
pubmed:meshHeading
pubmed-meshheading:9024031-Aminobutyric Acids, pubmed-meshheading:9024031-Animals, pubmed-meshheading:9024031-Blood Pressure, pubmed-meshheading:9024031-Blood-Brain Barrier, pubmed-meshheading:9024031-Carotid Artery, Internal, pubmed-meshheading:9024031-Enzyme Inhibitors, pubmed-meshheading:9024031-Injections, Intra-Arterial, pubmed-meshheading:9024031-Male, pubmed-meshheading:9024031-Mannitol, pubmed-meshheading:9024031-NG-Nitroarginine Methyl Ester, pubmed-meshheading:9024031-Nitric Oxide, pubmed-meshheading:9024031-Nitric Oxide Synthase, pubmed-meshheading:9024031-Osmolar Concentration, pubmed-meshheading:9024031-Phenylephrine, pubmed-meshheading:9024031-Rats, pubmed-meshheading:9024031-Rats, Sprague-Dawley, pubmed-meshheading:9024031-Sydnones, pubmed-meshheading:9024031-Vasoconstrictor Agents, pubmed-meshheading:9024031-Vasodilator Agents
pubmed:year
1997
pubmed:articleTitle
Effects of nitric oxide on blood-brain barrier disruption caused by intracarotid injection of hyperosmolar mannitol in rats.
pubmed:affiliation
Department of Anesthesia, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, New Brunswick 08901-1977, USA.
pubmed:publicationType
Journal Article