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rdf:type |
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lifeskim:mentions |
umls-concept:C0007603,
umls-concept:C0039062,
umls-concept:C0039065,
umls-concept:C0084697,
umls-concept:C0330386,
umls-concept:C1167622,
umls-concept:C1420270,
umls-concept:C1506158,
umls-concept:C1506159,
umls-concept:C1622418,
umls-concept:C1817242
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pubmed:issue |
3
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pubmed:dateCreated |
1997-3-10
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pubmed:abstractText |
Neurotransmitter release requires the specific docking of synaptic vesicles to the presynaptic plasma membrane followed by a calcium-triggered fusion event. Herein we report a previously unsuspected interaction of the synaptic vesicle protein and likely calcium sensor synaptotagmin with the plasma membrane t-SNARE SNAP-25. This interaction appears to resolve the apparent paradox that synaptic vesicles are capable of docking even when VAMP (vesicle-associated membrane protein) or syntaxin is cleaved or deleted and suggests that two species of v-SNAREs (VAMP and synaptotagmin) and two species of t-SNAREs (SNAP-25 and syntaxin) interact to functionally dock synaptic vesicles.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/9023371-1314395,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9023371-1321498,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9023371-1334074,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9023371-1589771,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9023371-1881448,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9023371-1990290,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9023371-2007627,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9023371-2192256,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9023371-7298720,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9023371-7501022,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9023371-7546745,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9023371-7559535,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9023371-7641890,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9023371-7674951,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9023371-7780734,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9023371-7791877,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9023371-7791897,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9023371-7857643,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9023371-7957071,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9023371-7961655,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9023371-7969419,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9023371-7993622,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9023371-8011337,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9023371-8060616,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9023371-8087843,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9023371-8119912,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9023371-8221884,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9023371-8247129,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9023371-8253763,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9023371-8439414,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9023371-8455717,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9023371-8559250,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9023371-8602507,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9023371-8692999,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9023371-8702751,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9023371-8771234,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9023371-8816825,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9023371-8861939,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9023371-8917590,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9023371-9023331
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Botulinum Toxins,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Qa-SNARE Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/R-SNARE Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Fusion Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/SNARE Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Synaptosomal-Associated Protein 25,
http://linkedlifedata.com/resource/pubmed/chemical/Synaptotagmins,
http://linkedlifedata.com/resource/pubmed/chemical/Vesicular Transport Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/botulinum toxin type E
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
4
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pubmed:volume |
94
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
997-1001
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:9023371-Animals,
pubmed-meshheading:9023371-Cattle,
pubmed-meshheading:9023371-Botulinum Toxins,
pubmed-meshheading:9023371-Cerebral Cortex,
pubmed-meshheading:9023371-Membrane Proteins,
pubmed-meshheading:9023371-Cell Membrane,
pubmed-meshheading:9023371-Nerve Tissue Proteins,
pubmed-meshheading:9023371-Synaptic Transmission,
pubmed-meshheading:9023371-Presynaptic Terminals,
pubmed-meshheading:9023371-Synaptic Vesicles,
pubmed-meshheading:9023371-Membrane Glycoproteins,
pubmed-meshheading:9023371-Calcium-Binding Proteins,
pubmed-meshheading:9023371-Recombinant Fusion Proteins,
pubmed-meshheading:9023371-Vesicular Transport Proteins,
pubmed-meshheading:9023371-R-SNARE Proteins
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