| pubmed-article:9023368 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9023368 | lifeskim:mentions | umls-concept:C1261473 | lld:lifeskim |
| pubmed-article:9023368 | lifeskim:mentions | umls-concept:C0078058 | lld:lifeskim |
| pubmed-article:9023368 | lifeskim:mentions | umls-concept:C0596138 | lld:lifeskim |
| pubmed-article:9023368 | lifeskim:mentions | umls-concept:C0018284 | lld:lifeskim |
| pubmed-article:9023368 | lifeskim:mentions | umls-concept:C1171892 | lld:lifeskim |
| pubmed-article:9023368 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:9023368 | pubmed:dateCreated | 1997-3-10 | lld:pubmed |
| pubmed-article:9023368 | pubmed:abstractText | Kaposi sarcoma (KS) is the most common tumor associated with HIV-1 infection and develops in nearly 30% of cases. The principal features of this tumor are abnormal vascularization and the proliferation of endothelial cells and spindle (tumor) cells. KS-derived spindle cells induce vascular lesions and display enhanced vascular permeability when inoculated subcutaneously in the nude mouse. This finding suggests that angiogenesis and capillary permeability play a central role in the development and progression of KS. In this study, we show that AIDS-KS cell lines express higher levels of vascular endothelial growth factor/vascular permeability factor (VEGF/VGF) than either human umbilical vein endothelial cells or human aortic smooth muscle cells. AIDS-KS cells and primary tumor tissues also expressed high levels of Flt-1 and KDR, the receptors for VEGF, while the normal skin of the same patients did not show any expression. We further demonstrate that VEGF antisense oligonucleotides AS-1 and AS-3 specifically block VEGF mRNA and protein production and inhibit KS cell growth in a dose-dependent manner. Furthermore, growth of KS cells in nude mice was specifically inhibited by VEGF antisense oligonucleotides. These results show that VEGF is an autocrine growth factor for AIDS-KS cells. To our knowledge, this is the first report that shows that VEGF acts as a growth stimulator in a human tumor. Inhibitors of VEGF or its cognate receptors may thus be candidates for therapeutic intervention. | lld:pubmed |
| pubmed-article:9023368 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9023368 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9023368 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9023368 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9023368 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9023368 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9023368 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9023368 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9023368 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9023368 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9023368 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9023368 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9023368 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9023368 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9023368 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9023368 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9023368 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9023368 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9023368 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9023368 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9023368 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9023368 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9023368 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9023368 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9023368 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9023368 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9023368 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9023368 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9023368 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9023368 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9023368 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9023368 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9023368 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9023368 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9023368 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9023368 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9023368 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9023368 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9023368 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9023368 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9023368 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9023368 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9023368 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9023368 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9023368 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9023368 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9023368 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9023368 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9023368 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9023368 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9023368 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9023368 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9023368 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9023368 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9023368 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9023368 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:9023368 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:9023368 | pubmed:author | pubmed-author:GillP SPS | lld:pubmed |
| pubmed-article:9023368 | pubmed:author | pubmed-author:SmithD LDL | lld:pubmed |
| pubmed-article:9023368 | pubmed:author | pubmed-author:CaoPP | lld:pubmed |
| pubmed-article:9023368 | pubmed:author | pubmed-author:ZhengTT | lld:pubmed |
| pubmed-article:9023368 | pubmed:author | pubmed-author:MasoodRR | lld:pubmed |
| pubmed-article:9023368 | pubmed:author | pubmed-author:NaiduYY | lld:pubmed |
| pubmed-article:9023368 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9023368 | pubmed:day | 4 | lld:pubmed |
| pubmed-article:9023368 | pubmed:volume | 94 | lld:pubmed |
| pubmed-article:9023368 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9023368 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9023368 | pubmed:pagination | 979-84 | lld:pubmed |
| pubmed-article:9023368 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:9023368 | pubmed:meshHeading | pubmed-meshheading:9023368-... | lld:pubmed |
| pubmed-article:9023368 | pubmed:meshHeading | pubmed-meshheading:9023368-... | lld:pubmed |
| pubmed-article:9023368 | pubmed:meshHeading | pubmed-meshheading:9023368-... | lld:pubmed |
| pubmed-article:9023368 | pubmed:meshHeading | pubmed-meshheading:9023368-... | lld:pubmed |
| pubmed-article:9023368 | pubmed:meshHeading | pubmed-meshheading:9023368-... | lld:pubmed |
| pubmed-article:9023368 | pubmed:meshHeading | pubmed-meshheading:9023368-... | lld:pubmed |
| pubmed-article:9023368 | pubmed:meshHeading | pubmed-meshheading:9023368-... | lld:pubmed |
| pubmed-article:9023368 | pubmed:meshHeading | pubmed-meshheading:9023368-... | lld:pubmed |
| pubmed-article:9023368 | pubmed:meshHeading | pubmed-meshheading:9023368-... | lld:pubmed |
| pubmed-article:9023368 | pubmed:meshHeading | pubmed-meshheading:9023368-... | lld:pubmed |
| pubmed-article:9023368 | pubmed:meshHeading | pubmed-meshheading:9023368-... | lld:pubmed |
| pubmed-article:9023368 | pubmed:meshHeading | pubmed-meshheading:9023368-... | lld:pubmed |
| pubmed-article:9023368 | pubmed:meshHeading | pubmed-meshheading:9023368-... | lld:pubmed |
| pubmed-article:9023368 | pubmed:meshHeading | pubmed-meshheading:9023368-... | lld:pubmed |
| pubmed-article:9023368 | pubmed:meshHeading | pubmed-meshheading:9023368-... | lld:pubmed |
| pubmed-article:9023368 | pubmed:meshHeading | pubmed-meshheading:9023368-... | lld:pubmed |
| pubmed-article:9023368 | pubmed:meshHeading | pubmed-meshheading:9023368-... | lld:pubmed |
| pubmed-article:9023368 | pubmed:meshHeading | pubmed-meshheading:9023368-... | lld:pubmed |
| pubmed-article:9023368 | pubmed:meshHeading | pubmed-meshheading:9023368-... | lld:pubmed |
| pubmed-article:9023368 | pubmed:meshHeading | pubmed-meshheading:9023368-... | lld:pubmed |
| pubmed-article:9023368 | pubmed:meshHeading | pubmed-meshheading:9023368-... | lld:pubmed |
