| pubmed-article:9022025 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9022025 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:9022025 | lifeskim:mentions | umls-concept:C0034790 | lld:lifeskim |
| pubmed-article:9022025 | lifeskim:mentions | umls-concept:C0035253 | lld:lifeskim |
| pubmed-article:9022025 | lifeskim:mentions | umls-concept:C0425152 | lld:lifeskim |
| pubmed-article:9022025 | lifeskim:mentions | umls-concept:C1332709 | lld:lifeskim |
| pubmed-article:9022025 | lifeskim:mentions | umls-concept:C0376315 | lld:lifeskim |
| pubmed-article:9022025 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:9022025 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:9022025 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:9022025 | lifeskim:mentions | umls-concept:C0332120 | lld:lifeskim |
| pubmed-article:9022025 | lifeskim:mentions | umls-concept:C1514485 | lld:lifeskim |
| pubmed-article:9022025 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:9022025 | pubmed:dateCreated | 1997-3-5 | lld:pubmed |
| pubmed-article:9022025 | pubmed:abstractText | JJ316 and JJ319 are rat CD28-specific monoclonal antibodies (mAb) of the gamma1 kappa isotype with identical co-stimulatory potency. At a concentration 100-1000-fold higher than that required for co-stimulation, JJ316, but not JJ319 induces massive proliferation of all T cell subsets in vitro without T cell receptor (TCR) triggering. "Direct" stimulation by JJ316 is fully blocked by JJ319, indicating that it is not due to cross-reactivity of JJ316 with the TCR complex or other activating receptors. JJ316 binds much more slowly to primary T cells than JJ319, whereas both antibodies bind with similar kinetics to CD28-transfected L-929 cells, suggesting that JJ316 binding to T cells requires redistribution or a conformational change of CD28. In vivo, JJ316 but not JJ319 induces rapid and transient proliferation of most CD4 T cells and, indirectly, of B cells. These data show that TCR engagement is not an absolute prerequisite either in vitro or in vivo for the induction of T cell proliferation through CD28 and suggest that mAb JJ316 is able to stimulate resting T cells directly by recruiting CD28 molecules from an inactive to an active form. | lld:pubmed |
| pubmed-article:9022025 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9022025 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9022025 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9022025 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:9022025 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9022025 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:9022025 | pubmed:issn | 0014-2980 | lld:pubmed |
| pubmed-article:9022025 | pubmed:author | pubmed-author:HankeTT | lld:pubmed |
| pubmed-article:9022025 | pubmed:author | pubmed-author:HünigTT | lld:pubmed |
| pubmed-article:9022025 | pubmed:author | pubmed-author:RousseauP YPY | lld:pubmed |
| pubmed-article:9022025 | pubmed:author | pubmed-author:TackeMM | lld:pubmed |
| pubmed-article:9022025 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9022025 | pubmed:volume | 27 | lld:pubmed |
| pubmed-article:9022025 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9022025 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9022025 | pubmed:pagination | 239-47 | lld:pubmed |
| pubmed-article:9022025 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:9022025 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9022025 | pubmed:articleTitle | CD28-mediated induction of proliferation in resting T cells in vitro and in vivo without engagement of the T cell receptor: evidence for functionally distinct forms of CD28. | lld:pubmed |
| pubmed-article:9022025 | pubmed:affiliation | Institute for Virology and Immunobiology, University of Würzburg, Germany. | lld:pubmed |
| pubmed-article:9022025 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9022025 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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