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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1997-4-15
|
| pubmed:abstractText |
Since 1981, the Children's Cancer and Leukemia Study Group (CCLSG) has developed a series of protocols for treatment of acute lymphoblastic leukemia (ALL) in childhood. In the first randomized controlled study of the 811 protocol (1981-1983) a comparison of conventional daily 6-mercaptopurine and methotrexate with a pulsed regimen of the two drugs was performed. The superiority of the pulsed regimen was shown. In the next 841 protocol (1984-1987) a comparison of two drugs and three drugs during induction therapy was conducted. The three-drug regimen resulted in a significantly higher event-free survival (EFS) rate. In the 874 protocol (1987-1990) two regimens with or without cranial irradiation were randomly compared, and there was no significant difference between the two regimens for the standard-risk group. To further improve the EFS rate a risk group-directed protocol 911 was conducted starting in January 1991. Life-table analysis of serial CCLSG protocols revealed that the outcome of overall ALL has gradually improved with an increase of the EFS rate; 41.4% +/- 3.6% at 14 years for the 811 protocol, 51.3% +/- 3.5% at 11 years for the 841 protocol, 56.7% +/- 3.1% at 8 years for the 874 protocol, and 78.2% +/- 3.1% at 4 years for the more recent 911 protocol.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0888-0018
|
| pubmed:author |
pubmed-author:AriyoshiNN,
pubmed-author:AsamiKK,
pubmed-author:FujimotoTT,
pubmed-author:FuruyamaTT,
pubmed-author:GushikenTT,
pubmed-author:IshidaYY,
pubmed-author:IwaiAA,
pubmed-author:KawakamiKK,
pubmed-author:KikutaAA,
pubmed-author:KimuraKK,
pubmed-author:KoizumiSS,
pubmed-author:MatsushitaTT,
pubmed-author:MimayaJJ,
pubmed-author:MiyakeMM,
pubmed-author:NinomiyaTT,
pubmed-author:NishikawaKK,
pubmed-author:OhtaSS,
pubmed-author:OkaTT,
pubmed-author:SekineII,
pubmed-author:ShimokawaTT,
pubmed-author:TakaueYY,
pubmed-author:TsuchiyaTT,
pubmed-author:WatanabeSS,
pubmed-author:YamamuraYY,
pubmed-author:YanaseTT
|
| pubmed:issnType |
Print
|
| pubmed:volume |
14
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
17-28
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:9021810-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:9021810-Child,
pubmed-meshheading:9021810-Child, Preschool,
pubmed-meshheading:9021810-Combined Modality Therapy,
pubmed-meshheading:9021810-Disease-Free Survival,
pubmed-meshheading:9021810-Female,
pubmed-meshheading:9021810-Humans,
pubmed-meshheading:9021810-Japan,
pubmed-meshheading:9021810-Life Tables,
pubmed-meshheading:9021810-Male,
pubmed-meshheading:9021810-Precursor Cell Lymphoblastic Leukemia-Lymphoma,
pubmed-meshheading:9021810-Randomized Controlled Trials as Topic,
pubmed-meshheading:9021810-Treatment Outcome
|
| pubmed:articleTitle |
Overview of clinical studies of childhood acute lymphoblastic leukemia for more than ten years by the Japanese Children's Cancer and Leukemia Study Group.
|
| pubmed:affiliation |
Department of Pediatrics, Kanazawa University School of Medicine, Japan.
|
| pubmed:publicationType |
Journal Article,
Review,
Research Support, Non-U.S. Gov't
|