Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1997-3-10
|
| pubmed:databankReference | |
| pubmed:abstractText |
Pleiomorphic adenoma of the salivary glands is a benign epithelial tumour occurring primarily in the major and minor salivary glands. It is by far the most common type of salivary gland tumour. Microscopically, pleiomorphic adenomas show a marked histological diversity with epithelial, myoepithelial and mesenchymal components in a variety of patterns. In addition to a cytogenetic subgroup with normal karyotypes, pleiomorphic adenomas are characterized by recurrent chromosome rearrangements, particularly reciprocal translocations, with breakpoints at 8q12, 3p21, and 12q13-15, in that order of frequency. The most common abnormality is a reciprocal t(3;8)(p21;q12). We here demonstrate that the t(3;8)(p21;q12) results in promoter swapping between PLAG1, a novel, developmentally regulated zinc finger gene at 8q12, and the constitutively expressed gene for beta-catenin (CTNNB1), a protein interface functioning in the WG/WNT signalling pathway and specification of cell fate during embryogenesis. Fusions occur in the 5'-non-coding regions of both genes, exchanging regulatory control elements while preserving the coding sequences. Due to the t(3;8)(p21;q12), PLAG1 is activated and expression levels of CTNNB1 are reduced. Activation of PLAG1 was also observed in an adenoma with a variant translocation t(8;15)(q12;q14). Our results indicate that PLAG1 activation due to promoter swapping is a crucial event in salivary gland tumourigenesis.
|
| pubmed:commentsCorrections | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/CTNNB1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Cytoskeletal Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Oncogene Proteins, Fusion,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/beta Catenin
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
1061-4036
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
15
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
170-4
|
| pubmed:dateRevised |
2008-11-21
|
| pubmed:meshHeading |
pubmed-meshheading:9020842-Adenoma, Pleomorphic,
pubmed-meshheading:9020842-Amino Acid Sequence,
pubmed-meshheading:9020842-Base Sequence,
pubmed-meshheading:9020842-Chromosome Walking,
pubmed-meshheading:9020842-Chromosomes, Artificial, Yeast,
pubmed-meshheading:9020842-Chromosomes, Human, Pair 3,
pubmed-meshheading:9020842-Chromosomes, Human, Pair 8,
pubmed-meshheading:9020842-Cytoskeletal Proteins,
pubmed-meshheading:9020842-DNA-Binding Proteins,
pubmed-meshheading:9020842-Genes,
pubmed-meshheading:9020842-Humans,
pubmed-meshheading:9020842-Molecular Sequence Data,
pubmed-meshheading:9020842-Oncogene Proteins, Fusion,
pubmed-meshheading:9020842-Promoter Regions, Genetic,
pubmed-meshheading:9020842-Salivary Gland Neoplasms,
pubmed-meshheading:9020842-Sequence Alignment,
pubmed-meshheading:9020842-Sequence Homology, Amino Acid,
pubmed-meshheading:9020842-Trans-Activators,
pubmed-meshheading:9020842-Translocation, Genetic,
pubmed-meshheading:9020842-Zinc Fingers,
pubmed-meshheading:9020842-beta Catenin
|
| pubmed:year |
1997
|
| pubmed:articleTitle |
Promoter swapping between the genes for a novel zinc finger protein and beta-catenin in pleiomorphic adenomas with t(3;8)(p21;q12) translocations.
|
| pubmed:affiliation |
Laboratory for Molecular Oncology, University of Leuven, Belgium.
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|