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rdf:type |
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lifeskim:mentions |
umls-concept:C0000545,
umls-concept:C0006141,
umls-concept:C0014486,
umls-concept:C0034693,
umls-concept:C0041712,
umls-concept:C0282515,
umls-concept:C0596263,
umls-concept:C0929301,
umls-concept:C1367459,
umls-concept:C1522552,
umls-concept:C1705819,
umls-concept:C2348308
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pubmed:issue |
3
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pubmed:dateCreated |
1997-3-3
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pubmed:abstractText |
We investigated the effects of low-dose eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) on the incidence and growth of 7,12-dimethylbenz(a)anthracene (DMBA)-induced mammary carcinoma in rats fed a high-fat (HF) diet. We also examined the effects of these treatments on the fatty acid composition of tumour and serum. Tumour incidence was significantly decreased by the administration of low-dose EPA and DHA, whereas their inhibitory effects on tumour growth did not reach significance. Serum arachidonic acid (AA) level was decreased by the administration of low-dose EPA and tended to be decreased by the administration of low-dose DHA, whereas tumour AA levels were not changed. The administration of low-dose EPA and DHA may be useful for inhibiting the incidence of breast cancer.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/9020478-13362715,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9020478-13428781,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9020478-2225334,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9020478-2232934,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9020478-2510582,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9020478-2538226,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9020478-2554913,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9020478-2710648,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9020478-2767851,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9020478-2994115,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9020478-3026166,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9020478-3114735,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9020478-3143882,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9020478-3342019,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9020478-3476790,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9020478-3541567,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9020478-3858582,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9020478-3919946,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9020478-6087007,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9020478-6093889,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9020478-6154736,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9020478-6304720,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9020478-6407750,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9020478-7342141,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9020478-7478431,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9020478-7644559,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9020478-7752256,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9020478-7777237,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9020478-7803721,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9020478-8234213,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9020478-8316054,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9020478-8784475
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0007-0920
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
75
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
348-53
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pubmed:dateRevised |
2010-9-13
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pubmed:meshHeading |
pubmed-meshheading:9020478-9,10-Dimethyl-1,2-benzanthracene,
pubmed-meshheading:9020478-Animals,
pubmed-meshheading:9020478-Anticarcinogenic Agents,
pubmed-meshheading:9020478-Body Weight,
pubmed-meshheading:9020478-Carcinogens,
pubmed-meshheading:9020478-Cell Division,
pubmed-meshheading:9020478-Diet, Fat-Restricted,
pubmed-meshheading:9020478-Dietary Fats,
pubmed-meshheading:9020478-Docosahexaenoic Acids,
pubmed-meshheading:9020478-Eicosapentaenoic Acid,
pubmed-meshheading:9020478-Fatty Acids, Nonesterified,
pubmed-meshheading:9020478-Female,
pubmed-meshheading:9020478-Mammary Neoplasms, Experimental,
pubmed-meshheading:9020478-Rats,
pubmed-meshheading:9020478-Rats, Sprague-Dawley
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pubmed:year |
1997
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pubmed:articleTitle |
Chemoprevention of DMBA-induced mammary carcinogenesis in rats by low-dose EPA and DHA.
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pubmed:affiliation |
Operation Center, Kanazawa University Hospital, Takara-machi, Japan.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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