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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5302
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pubmed:dateCreated |
1997-3-10
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pubmed:abstractText |
A lymphocyte population that expresses surface markers found on T cells and natural killer (NK) cells secretes large amounts of interleukin-4 (IL-4) immediately after T cell receptor ligation. These NK-like T cells are thus thought to be important for the initiation of type 2 T helper cell (TH2) responses. CD1-deficient mice were found to lack this lymphocyte subset, but they could nevertheless mount a protypical TH2 response; after immunization with antibody to immunoglobulin D (IgD), CD1-deficient mice produced IgE. Thus, although dependent on CD1 for their development, IL-4-secreting NK-like T cells are not required for TH2 responses.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies,
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Anti-Idiotypic,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD1,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD3,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin D,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin E,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-4,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, T-Cell,
http://linkedlifedata.com/resource/pubmed/chemical/beta 2-Microglobulin
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0036-8075
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
14
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pubmed:volume |
275
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
977-9
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:9020080-Animals,
pubmed-meshheading:9020080-Antibodies,
pubmed-meshheading:9020080-Antibodies, Anti-Idiotypic,
pubmed-meshheading:9020080-Antigens, CD1,
pubmed-meshheading:9020080-Antigens, CD3,
pubmed-meshheading:9020080-Cells, Cultured,
pubmed-meshheading:9020080-Gene Targeting,
pubmed-meshheading:9020080-Immunoglobulin D,
pubmed-meshheading:9020080-Immunoglobulin E,
pubmed-meshheading:9020080-Immunophenotyping,
pubmed-meshheading:9020080-Interferon-gamma,
pubmed-meshheading:9020080-Interleukin-4,
pubmed-meshheading:9020080-Killer Cells, Natural,
pubmed-meshheading:9020080-Mice,
pubmed-meshheading:9020080-Mice, Inbred BALB C,
pubmed-meshheading:9020080-Mice, Inbred C57BL,
pubmed-meshheading:9020080-RNA, Messenger,
pubmed-meshheading:9020080-Receptors, Antigen, T-Cell,
pubmed-meshheading:9020080-T-Lymphocyte Subsets,
pubmed-meshheading:9020080-Th2 Cells,
pubmed-meshheading:9020080-beta 2-Microglobulin
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pubmed:year |
1997
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pubmed:articleTitle |
Immunoglobulin E production in the absence of interleukin-4-secreting CD1-dependent cells.
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pubmed:affiliation |
Department of Cancer Biology, Harvard School of Public Health (HSPH), Boston, MA 02115, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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