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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5302
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pubmed:dateCreated |
1997-3-10
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pubmed:abstractText |
Cancers of the microsatellite mutator phenotype (MMP) show exaggerated genomic instability at simple repeat sequences. More than 50 percent (21 out of 41) of human MMP+ colon adenocarcinomas examined were found to have frameshift mutations in a tract of eight deoxyguanosines [(G)8] within BAX, a gene that promotes apoptosis. These mutations were absent in MMP- tumors and were significantly less frequent in (G)8 repeats from other genes. Frameshift mutations were present in both BAX alleles in some MMP+ colon tumor cell lines and in primary tumors. These results suggest that inactivating BAX mutations are selected for during the progression of colorectal MMP+ tumors and that the wild-type BAX gene plays a suppressor role in a p53-independent pathway for colorectal carcinogenesis.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0036-8075
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
14
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pubmed:volume |
275
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
967-9
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:9020077-Adenocarcinoma,
pubmed-meshheading:9020077-Alleles,
pubmed-meshheading:9020077-Apoptosis,
pubmed-meshheading:9020077-Base Sequence,
pubmed-meshheading:9020077-Colonic Neoplasms,
pubmed-meshheading:9020077-Frameshift Mutation,
pubmed-meshheading:9020077-Gene Expression,
pubmed-meshheading:9020077-Genes, Tumor Suppressor,
pubmed-meshheading:9020077-Humans,
pubmed-meshheading:9020077-Microsatellite Repeats,
pubmed-meshheading:9020077-Molecular Sequence Data,
pubmed-meshheading:9020077-Mutation,
pubmed-meshheading:9020077-Phenotype,
pubmed-meshheading:9020077-Polymerase Chain Reaction,
pubmed-meshheading:9020077-Proto-Oncogene Proteins,
pubmed-meshheading:9020077-Proto-Oncogene Proteins c-bcl-2,
pubmed-meshheading:9020077-Sequence Deletion,
pubmed-meshheading:9020077-Tumor Cells, Cultured,
pubmed-meshheading:9020077-bcl-2-Associated X Protein
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pubmed:year |
1997
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pubmed:articleTitle |
Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype.
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pubmed:affiliation |
The Burnham Institute, La Jolla Cancer Research Center, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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