9018776

Source:http://linkedlifedata.com/resource/pubmed/id/9018776

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0008848, umls-concept:C0027573, umls-concept:C0031529, umls-concept:C0206173, umls-concept:C0349395
pubmed:issue	1
pubmed:dateCreated	1997-3-20
pubmed:abstractText	Failure of gonococcal infections to respond to 500 mg of ciprofloxacin or 400 mg of ofloxacin has been reported from Australia, the United Kingdom, and the United States. Recently, high rates of decreased susceptibility to the fluoroquinolones have been detected in penicillinase-producing Neisseria gonorrhoeae in the Republic of the Philippines.
pubmed:grant	http://linkedlifedata.com/resource/pubmed/grant/AI31448
pubmed:keyword	http://linkedlifedata.com/resource/pubmed/keyword/Asia, http://linkedlifedata.com/resource/pubmed/keyword/Behavior, http://linkedlifedata.com/resource/pubmed/keyword/Clinical Research, http://linkedlifedata.com/resource/pubmed/keyword/DRUGS, http://linkedlifedata.com/resource/pubmed/keyword/Developing Countries, http://linkedlifedata.com/resource/pubmed/keyword/Diseases, http://linkedlifedata.com/resource/pubmed/keyword/GONORRHEA, http://linkedlifedata.com/resource/pubmed/keyword/In Vitro, http://linkedlifedata.com/resource/pubmed/keyword/Infections, http://linkedlifedata.com/resource/pubmed/keyword/Measurement, http://linkedlifedata.com/resource/pubmed/keyword/PHILIPPINES, http://linkedlifedata.com/resource/pubmed/keyword/Prevalence, http://linkedlifedata.com/resource/pubmed/keyword/Prostitutes--women, http://linkedlifedata.com/resource/pubmed/keyword/Reproductive Tract Infections, http://linkedlifedata.com/resource/pubmed/keyword/Research Methodology, http://linkedlifedata.com/resource/pubmed/keyword/Research Report, http://linkedlifedata.com/resource/pubmed/keyword/Sex Behavior, http://linkedlifedata.com/resource/pubmed/keyword/Sexually Transmitted Diseases, http://linkedlifedata.com/resource/pubmed/keyword/Southeastern Asia, http://linkedlifedata.com/resource/pubmed/keyword/Treatment
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/7705941
pubmed:citationSubset	IM
pubmed:status	MEDLINE
pubmed:month	Jan
pubmed:issn	0148-5717
pubmed:author	pubmed-author:KnappJ SJS, pubmed-author:ManalastasRR, pubmed-author:MesolaV PVP, pubmed-author:P'anS YSY, pubmed-author:PLANN, pubmed-author:PerineP LPL, pubmed-author:TuazonCC, pubmed-author:WhittingtonW LWL
pubmed:issnType	Print
pubmed:volume	24
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	2-7
pubmed:dateRevised	2009-11-19
pubmed:otherAbstract	PIP: During July-October 1994 in the Philippines, Neisseria gonorrhoeae were isolated from 92 female sex workers in Manila and Cebu City. The purpose was to characterize the gonococcal strains by plasmid content, auxotype, serovar, and antimicrobial susceptibilities in order to examine the diversity of antimicrobial-resistant N gonorrhoeae strains in these sex workers. Penicillinase-producing N gonorrhoeae (PPNG) comprised 70.7% of the isolates. Strains with the 3.2-megadalton (Mda) beta-lactamase plasmid were more common in Cebu City than in Manila (57.8% vs. 28.6%; p = 0.02). They had significantly lower minimum inhibitory concentrations (MICs) to penicillin, tetracycline, ceftriaxone, ciprofloxacin, and erythromycin than did strains with 3.05-, 3.9-, or 4.4-Mda plasmid (p 0.01). One PPNG strain had a previously undescribed 3.9-Mda beta-lactamase plasmid. It also had a 24.5-Mda conjugative plasmid. Only 15.2% of all 92 isolates were susceptible to both penicillin and tetracycline. Tetracycline-resistant N gonorrhoeae (TRNG) comprised 6.5% of the isolates. 1.1% of isolates were resistant to both penicillin and tetracycline. 54.3% of all strains were resistant to nalidixic acid (fluoroquinolone), 84% of which had MICs of at least 0.125 mcg/ml ciprofloxacin. 68% of the nalidixic acid-resistant strains had 4.4 Mda beta-lactamase plasmids. 85.9% of all gonococcal isolates exhibited resistance to penicillin or tetracycline. They also included strains exhibiting resistance to fluoroquninolones. These findings reveal the need for periodic surveillance for resistance in N gonorrhoeae to the antimicrobial agents used for primary gonorrhea therapy in order to improve the treatments of choice.
pubmed:meshHeading	pubmed-meshheading:9018776-Drug Resistance, Microbial, pubmed-meshheading:9018776-Female, pubmed-meshheading:9018776-Gonorrhea, pubmed-meshheading:9018776-Humans, pubmed-meshheading:9018776-Microbial Sensitivity Tests, pubmed-meshheading:9018776-Molecular Epidemiology, pubmed-meshheading:9018776-Neisseria gonorrhoeae, pubmed-meshheading:9018776-Philippines, pubmed-meshheading:9018776-Prostitution, pubmed-meshheading:9018776-R Factors, pubmed-meshheading:9018776-Serotyping, pubmed-meshheading:9018776-Urban Health
pubmed:year	1997
pubmed:articleTitle	Molecular epidemiology, in 1994, of Neisseria gonorrhoeae in Manila and Cebu City, Republic of the Philippines.
pubmed:affiliation	Division of Sexually Transmitted Diseases Laboratory Research, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA.
pubmed:publicationType	Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S.