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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1997-5-9
|
| pubmed:abstractText |
Although respiratory distress syndrome (RDS) is a leading cause of neonatal morbidity and mortality in the west, there are few data on the prevalence and spectrum of RDS from developing countries. Available evidence suggests that the disorder may be less common than the overall 1% incidence reported from developed countries. In a prospective study of the prevalence of RDS in a consecutive 10,134 births at the Aga Khan University Hospital, we documented the disorder in 127 (1.2% births), with a prevalence of 12.8% among low birthweight infants. The overall mortality for this group was 39%, with the highest mortality rate (68%) among newborn infants < or = 1000 g birthweight. Our data from a large and relatively well-nourished hospital-born population in Karachi suggest that RDS is a significant cause of morbidity and mortality in preterm infants with a similar prevalence rate to western figures.
|
| pubmed:keyword |
http://linkedlifedata.com/resource/pubmed/keyword/Age Factors,
http://linkedlifedata.com/resource/pubmed/keyword/Asia,
http://linkedlifedata.com/resource/pubmed/keyword/Biology,
http://linkedlifedata.com/resource/pubmed/keyword/Birth Weight,
http://linkedlifedata.com/resource/pubmed/keyword/Body Weight,
http://linkedlifedata.com/resource/pubmed/keyword/Demographic Factors,
http://linkedlifedata.com/resource/pubmed/keyword/Developing Countries,
http://linkedlifedata.com/resource/pubmed/keyword/Diseases,
http://linkedlifedata.com/resource/pubmed/keyword/Infant,
http://linkedlifedata.com/resource/pubmed/keyword/Infant, Premature,
http://linkedlifedata.com/resource/pubmed/keyword/Infant Mortality,
http://linkedlifedata.com/resource/pubmed/keyword/Infections,
http://linkedlifedata.com/resource/pubmed/keyword/Low Birth Weight,
http://linkedlifedata.com/resource/pubmed/keyword/Measurement,
http://linkedlifedata.com/resource/pubmed/keyword/Mortality,
http://linkedlifedata.com/resource/pubmed/keyword/Pakistan,
http://linkedlifedata.com/resource/pubmed/keyword/Physiology,
http://linkedlifedata.com/resource/pubmed/keyword/Population,
http://linkedlifedata.com/resource/pubmed/keyword/Population Characteristics,
http://linkedlifedata.com/resource/pubmed/keyword/Population Dynamics,
http://linkedlifedata.com/resource/pubmed/keyword/Prevalence,
http://linkedlifedata.com/resource/pubmed/keyword/Prospective Studies,
http://linkedlifedata.com/resource/pubmed/keyword/Research Methodology,
http://linkedlifedata.com/resource/pubmed/keyword/Research Report,
http://linkedlifedata.com/resource/pubmed/keyword/Respiratory Infections,
http://linkedlifedata.com/resource/pubmed/keyword/Risk Factors,
http://linkedlifedata.com/resource/pubmed/keyword/Southern Asia,
http://linkedlifedata.com/resource/pubmed/keyword/Studies,
http://linkedlifedata.com/resource/pubmed/keyword/Youth
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
0269-5022
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
11
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
37-43
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| pubmed:dateRevised |
2004-11-17
|
| pubmed:otherAbstract |
PIP: A prospective study of the prevalence of respiratory distress syndrome (RDS) among newborns at the Aga Khan University Hospital in Karachi, Pakistan, revealed that this syndrome, also known as hyaline membrane disease, is a significant cause of morbidity and mortality in preterm infants. In the period January 1987 to December 1993, there were 10,134 births and 2003 admissions to the hospital's Neonatal Intensive Care Unit, of which 599 were primarily because of neonatal respiratory distress. 127 of these infants had a radiologic evidence and blood gas parameters indicative of RDS, giving an overall RDS prevalence of 12.1 cases per 1000 births in this cohort. The overall prevalence of RDS among low-birth-weight (2500 grams or under) infants was 12.8%. By birth weight category, the percentage of infants with RDS was as follows: 1000 grams or under, 25%; 1001-1500 grams, 51%; 1501-2500 grams, 45%; and over 2500 grams, 6%. The most common clinical features and complications among infants with RDS included cyanosis at presentation (76%), acidotic at admission (61%), grunting at presentation (59%), apneic since birth (28%), hypothermic at admission (27%), and patent ductus arteriosus (21%). Maternal risk factors included pregnancy-induced hypertension (28%), antepartum hemorrhage (21%), intrauterine growth retardation (17%), diabetes (5%), and prolonged rupture of the membranes (16%). There were 47 deaths among infants with RDS (39% mortality rate); the highest mortality (68%) was recorded among infants weighing 1000 grams or less at birth. The 1.2% RDS prevalence rate identified in this study is comparable to that in Western countries.
|
| pubmed:meshHeading |
pubmed-meshheading:9018726-Female,
pubmed-meshheading:9018726-Humans,
pubmed-meshheading:9018726-Infant, Low Birth Weight,
pubmed-meshheading:9018726-Infant, Newborn,
pubmed-meshheading:9018726-Male,
pubmed-meshheading:9018726-Pakistan,
pubmed-meshheading:9018726-Prevalence,
pubmed-meshheading:9018726-Prospective Studies,
pubmed-meshheading:9018726-Respiratory Distress Syndrome, Newborn,
pubmed-meshheading:9018726-Severity of Illness Index,
pubmed-meshheading:9018726-Socioeconomic Factors
|
| pubmed:year |
1997
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| pubmed:articleTitle |
Neonatal respiratory distress syndrome in Karachi: some epidemiological considerations.
|
| pubmed:affiliation |
Department of Paediatrics, Aga Khan University Hospital, Karachi, Pakistan.
|
| pubmed:publicationType |
Journal Article
|