Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
1997-2-21
pubmed:databankReference
pubmed:abstractText
Many isoprenylated proteins are known to participate in signal transduction, but not all have been identified. Using an in vitro prenylation screen, two human cDNAs (PTP(CAAXI) and PTP(CAAX2)) homologous to the rat PRL-1 and human OV-1 protein tyrosine phosphatase genes were identified. PTP(CAAXI) and PTP(CAAX2) were farnesylated in vitro by mammalian farnesyl:protein transferase, and epitope-tagged PTP(CAAX2) was prenylated in epithelial cells. Overexpression of PTP(CAAXI) and PTP(CAAX2) in epithelial cells caused a transformed phenotype in culture and tumor growth in nude mice. Thus, PTP(CAAXI) and PTP(CAAX2) represent a novel class of isoprenylated, oncogenic protein tyrosine phosphatases.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Alkyl and Aryl Transferases, http://linkedlifedata.com/resource/pubmed/chemical/Cell Cycle Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Immediate-Early Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Neoplasm Proteins, http://linkedlifedata.com/resource/pubmed/chemical/PTP4A1 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/PTP4A2 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Protein Tyrosine Phosphatases, http://linkedlifedata.com/resource/pubmed/chemical/Ptp4a1 protein, mouse, http://linkedlifedata.com/resource/pubmed/chemical/Ptp4a1 protein, rat, http://linkedlifedata.com/resource/pubmed/chemical/Transferases, http://linkedlifedata.com/resource/pubmed/chemical/geranylgeranyltransferase type-I, http://linkedlifedata.com/resource/pubmed/chemical/p21(ras) farnesyl-protein...
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0304-3835
pubmed:author
pubmed:issnType
Print
pubmed:day
20
pubmed:volume
110
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
49-55
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed-meshheading:9018080-Alkyl and Aryl Transferases, pubmed-meshheading:9018080-Amino Acid Sequence, pubmed-meshheading:9018080-Animals, pubmed-meshheading:9018080-Base Sequence, pubmed-meshheading:9018080-Cell Cycle Proteins, pubmed-meshheading:9018080-Cell Transformation, Neoplastic, pubmed-meshheading:9018080-Cricetinae, pubmed-meshheading:9018080-Humans, pubmed-meshheading:9018080-Immediate-Early Proteins, pubmed-meshheading:9018080-Membrane Proteins, pubmed-meshheading:9018080-Mice, pubmed-meshheading:9018080-Molecular Sequence Data, pubmed-meshheading:9018080-Neoplasm Proteins, pubmed-meshheading:9018080-Phenotype, pubmed-meshheading:9018080-Protein Prenylation, pubmed-meshheading:9018080-Protein Tyrosine Phosphatases, pubmed-meshheading:9018080-Transferases, pubmed-meshheading:9018080-Tumor Cells, Cultured
pubmed:year
1996
pubmed:articleTitle
Prenylation of oncogenic human PTP(CAAX) protein tyrosine phosphatases.
pubmed:affiliation
Department of Biology, Indiana University-Purdue University at Indianapolis, 46202, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't