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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
1997-3-5
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pubmed:abstractText |
Levels of free intracellular calcium have been measured on two cell lines of cultured human fibroblasts carrying the genetic lesions occurring in Duchenne and Becker dystrophies. Both cell lines elicited a markedly higher content of the cation (98 nM and 57 nM, respectively) than control fibroblasts (35 nM). Differences toward controls were statistically significant (p < 0.01). Dystrophic fibroblasts were also found to possess a significantly reduced amount by about 50% of muscular acylphosphatase isoenzyme as compared to normal cells. As acylphosphatase was demonstrated to be involved in the regulation of Ca2+-ATPase activity from different sources, a hypothesis was formulated that could explain the disruption of calcium homeostasis as an effect of the altered acylphosphatase activity.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0006-291X
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
13
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pubmed:volume |
230
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
327-30
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9016776-Acid Anhydride Hydrolases,
pubmed-meshheading:9016776-Adolescent,
pubmed-meshheading:9016776-Calcium,
pubmed-meshheading:9016776-Cell Division,
pubmed-meshheading:9016776-Cell Line,
pubmed-meshheading:9016776-Cells, Cultured,
pubmed-meshheading:9016776-Fibroblasts,
pubmed-meshheading:9016776-Humans,
pubmed-meshheading:9016776-Isoenzymes,
pubmed-meshheading:9016776-Male,
pubmed-meshheading:9016776-Muscle, Skeletal,
pubmed-meshheading:9016776-Muscular Dystrophies,
pubmed-meshheading:9016776-Reference Values,
pubmed-meshheading:9016776-Skin
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pubmed:year |
1997
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pubmed:articleTitle |
Alteration of free calcium levels and acylphosphatase muscular isoenzyme in cultured dystrophic skin fibroblasts.
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pubmed:affiliation |
Department of Biochemical Sciences, Università di Firenze, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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