Linked Life Data

9015797

Source:http://linkedlifedata.com/resource/pubmed/id/9015797

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1997-4-15
pubmed:abstractText
The following experiments were performed to ascertain the role of the nucleus accumbens in opiate-dopamine interactions using measures of locomotor activity. Three separate experiments were carried out. In Experiment 1, rats received systemic morphine (10 mg/kg IP) or saline (1 ml/kg IP) every other day for 5 days, followed by systemic amphetamine (1.5 mg/kg) 48 hours following the fifth injection. Animals in the morphine pretreatment group exhibited a sensitized locomotor response to amphetamine. In Experiment 2, animals received the same systemic pretreatment and were subsequently given intraaccumbens saline, amphetamine (2.5 micrograms/0.5 microliter) or cocaine (7 micrograms/0.5 microliter), each separated by 48 hours. Morphine-pretreated animals showed enhanced motor activity in response to intraaccumbens microinfusion of the psychostimulant drugs. Finally, in Experiment 3, multiple microinjections of morphine (0.5 microgram/0.5 microliter) directly into the nucleus accumbens resulted in a potentiated locomotor response to intraaccumbens amphetamine (2.5 micrograms/0.5 microliter). These data indicate that the nucleus accumbens may contribute to both the development and expression of opiate-stimulant cross-sensitization. The neural basis of this sensitization is hypothesized to be a common intracellular pathway affected by both classes of drugs, such as the cyclic adenosine monophosphate (AMP) system.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0893-133X
pubmed:author
pubmed:issnType
Print
pubmed:volume
16
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
147-55
pubmed:dateRevised
2011-5-18
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
Sensitization of the locomotor response to psychostimulants after repeated opiate exposure: role of the nucleus accumbens.
pubmed:affiliation
Institute of Animal Behavior, State University of New Jersey, Newark, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't