| pubmed-article:9015155 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9015155 | lifeskim:mentions | umls-concept:C0035804 | lld:lifeskim |
| pubmed-article:9015155 | lifeskim:mentions | umls-concept:C0227525 | lld:lifeskim |
| pubmed-article:9015155 | lifeskim:mentions | umls-concept:C0012899 | lld:lifeskim |
| pubmed-article:9015155 | lifeskim:mentions | umls-concept:C0033268 | lld:lifeskim |
| pubmed-article:9015155 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:9015155 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:9015155 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:9015155 | pubmed:dateCreated | 1997-2-27 | lld:pubmed |
| pubmed-article:9015155 | pubmed:abstractText | Incubation of both rat and mouse hepatocytes with 3-chloro-4-(dichloromethyl)-5-hydroxy-2[5H]-furanone (MX) in vitro resulted in a dose-dependent increase in unscheduled DNA synthesis (UDS) at sub-cytotoxic concentrations (1-10 microM MX; 20 h incubation). Depletion of glutathione stores by pre-treatment of rat hepatocytes with buthionine sulfoximine did not result in a significant increase in UDS produced by MX. In contrast, MX did not induce UDS in mouse hepatocytes ex vivo either 3 or 16 h following administration of a single oral dose of 100 mg/kg MX. Despite the ability of MX to produce repairable DNA damage, restricted access of MX to the liver may prevent a measurable UDS response in vivo. | lld:pubmed |
| pubmed-article:9015155 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9015155 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9015155 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9015155 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9015155 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9015155 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9015155 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9015155 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9015155 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9015155 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9015155 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:9015155 | pubmed:issn | 0027-5107 | lld:pubmed |
| pubmed-article:9015155 | pubmed:author | pubmed-author:DaviesJ EJE | lld:pubmed |
| pubmed-article:9015155 | pubmed:author | pubmed-author:ChipmanJ KJK | lld:pubmed |
| pubmed-article:9015155 | pubmed:author | pubmed-author:NunnJ WJW | lld:pubmed |
| pubmed-article:9015155 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9015155 | pubmed:day | 3 | lld:pubmed |
| pubmed-article:9015155 | pubmed:volume | 373 | lld:pubmed |
| pubmed-article:9015155 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9015155 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9015155 | pubmed:pagination | 67-73 | lld:pubmed |
| pubmed-article:9015155 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:9015155 | pubmed:meshHeading | pubmed-meshheading:9015155-... | lld:pubmed |
| pubmed-article:9015155 | pubmed:meshHeading | pubmed-meshheading:9015155-... | lld:pubmed |
| pubmed-article:9015155 | pubmed:meshHeading | pubmed-meshheading:9015155-... | lld:pubmed |
| pubmed-article:9015155 | pubmed:meshHeading | pubmed-meshheading:9015155-... | lld:pubmed |
| pubmed-article:9015155 | pubmed:meshHeading | pubmed-meshheading:9015155-... | lld:pubmed |
| pubmed-article:9015155 | pubmed:meshHeading | pubmed-meshheading:9015155-... | lld:pubmed |
| pubmed-article:9015155 | pubmed:meshHeading | pubmed-meshheading:9015155-... | lld:pubmed |
| pubmed-article:9015155 | pubmed:meshHeading | pubmed-meshheading:9015155-... | lld:pubmed |
| pubmed-article:9015155 | pubmed:meshHeading | pubmed-meshheading:9015155-... | lld:pubmed |
| pubmed-article:9015155 | pubmed:meshHeading | pubmed-meshheading:9015155-... | lld:pubmed |
| pubmed-article:9015155 | pubmed:meshHeading | pubmed-meshheading:9015155-... | lld:pubmed |
| pubmed-article:9015155 | pubmed:meshHeading | pubmed-meshheading:9015155-... | lld:pubmed |
| pubmed-article:9015155 | pubmed:meshHeading | pubmed-meshheading:9015155-... | lld:pubmed |
| pubmed-article:9015155 | pubmed:meshHeading | pubmed-meshheading:9015155-... | lld:pubmed |
| pubmed-article:9015155 | pubmed:meshHeading | pubmed-meshheading:9015155-... | lld:pubmed |
| pubmed-article:9015155 | pubmed:meshHeading | pubmed-meshheading:9015155-... | lld:pubmed |
| pubmed-article:9015155 | pubmed:meshHeading | pubmed-meshheading:9015155-... | lld:pubmed |
| pubmed-article:9015155 | pubmed:meshHeading | pubmed-meshheading:9015155-... | lld:pubmed |
| pubmed-article:9015155 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9015155 | pubmed:articleTitle | Production of unscheduled DNA synthesis in rodent hepatocytes in vitro, but not in vivo, by 3-chloro-4-(dichloromethyl)-5-hydroxy-2[5H]-furanone (MX). | lld:pubmed |
| pubmed-article:9015155 | pubmed:affiliation | School of Biochemistry, University of Birmingham, Edgbaston, UK. | lld:pubmed |
| pubmed-article:9015155 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9015155 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
