|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
1
|
|
pubmed:dateCreated |
1997-2-27
|
|
pubmed:abstractText |
Incubation of both rat and mouse hepatocytes with 3-chloro-4-(dichloromethyl)-5-hydroxy-2[5H]-furanone (MX) in vitro resulted in a dose-dependent increase in unscheduled DNA synthesis (UDS) at sub-cytotoxic concentrations (1-10 microM MX; 20 h incubation). Depletion of glutathione stores by pre-treatment of rat hepatocytes with buthionine sulfoximine did not result in a significant increase in UDS produced by MX. In contrast, MX did not induce UDS in mouse hepatocytes ex vivo either 3 or 16 h following administration of a single oral dose of 100 mg/kg MX. Despite the ability of MX to produce repairable DNA damage, restricted access of MX to the liver may prevent a measurable UDS response in vivo.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jan
|
|
pubmed:issn |
0027-5107
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
3
|
|
pubmed:volume |
373
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
67-73
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:9015155-Administration, Oral,
pubmed-meshheading:9015155-Animals,
pubmed-meshheading:9015155-Buthionine Sulfoximine,
pubmed-meshheading:9015155-Cells, Cultured,
pubmed-meshheading:9015155-DNA,
pubmed-meshheading:9015155-DNA Damage,
pubmed-meshheading:9015155-DNA Repair,
pubmed-meshheading:9015155-Dose-Response Relationship, Drug,
pubmed-meshheading:9015155-Furans,
pubmed-meshheading:9015155-Glutathione,
pubmed-meshheading:9015155-Humans,
pubmed-meshheading:9015155-Liver,
pubmed-meshheading:9015155-Male,
pubmed-meshheading:9015155-Mice,
pubmed-meshheading:9015155-Mice, Inbred BALB C,
pubmed-meshheading:9015155-Mutagens,
pubmed-meshheading:9015155-Rats,
pubmed-meshheading:9015155-Rats, Wistar
|
|
pubmed:year |
1997
|
|
pubmed:articleTitle |
Production of unscheduled DNA synthesis in rodent hepatocytes in vitro, but not in vivo, by 3-chloro-4-(dichloromethyl)-5-hydroxy-2[5H]-furanone (MX).
|
|
pubmed:affiliation |
School of Biochemistry, University of Birmingham, Edgbaston, UK.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
