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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1997-2-20
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pubmed:databankReference |
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pubmed:abstractText |
We have cloned a cDNA encoding a novel association partner of cyclin G by West-Western blotting. The cDNA encodes a protein that harbors a Ser/Thr protein kinase-like catalytic domain at the N-terminal. Hence, we named it GAK (cyclin G-associated kinase). The long C-terminal extension shares homology with tensin and auxilin, and contains a leucine zipper region. Co-immunoprecipitation and Western blotting showed that GAK and cyclin G associate together in vivo. GAK also co-precipitated with CDK5, and CDK5 was found to be associated with cyclin G. We also showed by BIAcore analysis that the GAK-cyclin G interaction was direct.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adaptor Proteins, Vesicular...,
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Ccng1 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclin G,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclin G1,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclin-Dependent Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclins,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Complementary,
http://linkedlifedata.com/resource/pubmed/chemical/Microfilament Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Fusion Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/tensins
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0014-5793
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
27
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pubmed:volume |
402
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
73-80
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:9013862-Adaptor Proteins, Vesicular Transport,
pubmed-meshheading:9013862-Amino Acid Sequence,
pubmed-meshheading:9013862-Antibodies, Monoclonal,
pubmed-meshheading:9013862-Blotting, Western,
pubmed-meshheading:9013862-Cloning, Molecular,
pubmed-meshheading:9013862-Cyclin G,
pubmed-meshheading:9013862-Cyclin G1,
pubmed-meshheading:9013862-Cyclin-Dependent Kinases,
pubmed-meshheading:9013862-Cyclins,
pubmed-meshheading:9013862-DNA, Complementary,
pubmed-meshheading:9013862-Kinetics,
pubmed-meshheading:9013862-Microfilament Proteins,
pubmed-meshheading:9013862-Molecular Sequence Data,
pubmed-meshheading:9013862-Nerve Tissue Proteins,
pubmed-meshheading:9013862-Phosphoproteins,
pubmed-meshheading:9013862-Precipitin Tests,
pubmed-meshheading:9013862-Protein-Serine-Threonine Kinases,
pubmed-meshheading:9013862-Recombinant Fusion Proteins
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pubmed:year |
1997
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pubmed:articleTitle |
GAK: a cyclin G associated kinase contains a tensin/auxilin-like domain.
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pubmed:affiliation |
Department of Molecular Genetics, Osaka University, Yamadaoka, Suita, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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