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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1997-2-20
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pubmed:databankReference |
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pubmed:abstractText |
We have cloned a novel Tcp-1-related mouse testis cDNA encoding a polypeptide of 531 amino acids which shares 81.2% identity with the zeta subunit of the mouse cytosolic chaperonin-containing TCP-1 (CCT). Immunoblot analysis of mouse testis CCT subunits separated by 2-dimensional gel electrophoresis indicates that this novel gene, Cctz-2, encodes a CCT subunit of Mr 57 000 and pI 7.1. Cctz-2 mRNA is detected only in testis whereas the other Cctz gene, Cctz-1, is expressed in all tissues investigated. The CCTzeta-2 subunit may have specific functions in the folding of testicular proteins and for interactions with testicular molecular chaperones.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0014-5793
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
27
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pubmed:volume |
402
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
53-6
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:9013858-Amino Acid Sequence,
pubmed-meshheading:9013858-Animals,
pubmed-meshheading:9013858-Blotting, Northern,
pubmed-meshheading:9013858-Chaperonin Containing TCP-1,
pubmed-meshheading:9013858-Chaperonins,
pubmed-meshheading:9013858-Cloning, Molecular,
pubmed-meshheading:9013858-DNA, Complementary,
pubmed-meshheading:9013858-Humans,
pubmed-meshheading:9013858-Immunoblotting,
pubmed-meshheading:9013858-Isoelectric Point,
pubmed-meshheading:9013858-Male,
pubmed-meshheading:9013858-Mice,
pubmed-meshheading:9013858-Molecular Sequence Data,
pubmed-meshheading:9013858-Molecular Weight,
pubmed-meshheading:9013858-Organ Specificity,
pubmed-meshheading:9013858-Testis
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pubmed:year |
1997
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pubmed:articleTitle |
Tissue-specific subunit of the mouse cytosolic chaperonin-containing TCP-1.
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pubmed:affiliation |
Institute of Cancer Research, Chester Beatty Laboratories, London, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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