| pubmed-article:9013082 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9013082 | lifeskim:mentions | umls-concept:C0006675 | lld:lifeskim |
| pubmed-article:9013082 | lifeskim:mentions | umls-concept:C0010453 | lld:lifeskim |
| pubmed-article:9013082 | lifeskim:mentions | umls-concept:C0596901 | lld:lifeskim |
| pubmed-article:9013082 | lifeskim:mentions | umls-concept:C1512199 | lld:lifeskim |
| pubmed-article:9013082 | lifeskim:mentions | umls-concept:C0032575 | lld:lifeskim |
| pubmed-article:9013082 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:9013082 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:9013082 | pubmed:dateCreated | 1997-6-19 | lld:pubmed |
| pubmed-article:9013082 | pubmed:abstractText | The effects of diadenosine tetraphosphate (AP4A) diadenosine pentaphosphate (AP5A) and diadenosine hexaphosphate (AP6A) on the cytosolic-free calcium concentration ([Ca2+]i) were evaluated in cultured rat glomerular mesangial cells (MCs) using the fluorescent dye technique. The addition of 10 mumol L-1 AP4A, AP5A or AP6A significantly increased [Ca2+]i in MCs by 57 +/- 9 nmol L-1 n = 17; P < 0.01), 76 +/- 27 nmol L-1 (n = 9; P < 0.01) or 65 +/- 12 nmol L-1 (n = 18; P < 0.01) respectively. In the absence of extracellular calcium, there was no significant change in [Ca2+]i in MCs after administration of diadenosine polyphosphates, indicating that these agents induce transplasma membrane Ca2+ influx. AP6A significantly enhanced the angiotensin II-induced changes in [Ca2+]i in MCs. The AP5A-induced transplasma membrane Ca2+ influx was inhibited by the P2 purinoceptor blockers suramin and pyridoxal-phosphate-6-azophenyl-2',4'-disulphonic acid (PPADS), but was not affected by the adenosine A1 receptor blocker 8-cyclopentyl-1.3-dipro-pylzanthine (CPDPX). Adenosine triphosphate (ATP) and adenosine 5'-O-(3-thio)triphosphate (ATP-gamma S) increased [Ca2+]i in MCs, whereas alpha, beta-methylene ATP had no effect on [Ca2+]i in MCs. Measurements of diacylglycerol and phosphatidic acid showed that AP5A and AP6A also stimulated phospholipase C, but had no effect on phospholipase D. The inhibition of phosphatidylcholine-specific phospholipase C significantly reduced the AP5A-induced [Ca2+]i increase. In summary, diadenosine polyphosphates induce Ca2+ influx through P2 purinoceptors and may be involved in the local regulation of vascular resistance evoked by the Ca(2+)-dependent contractile response of mesangial cells. | lld:pubmed |
| pubmed-article:9013082 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9013082 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9013082 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9013082 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9013082 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9013082 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9013082 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9013082 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9013082 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9013082 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9013082 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9013082 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9013082 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9013082 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9013082 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9013082 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9013082 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9013082 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9013082 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:9013082 | pubmed:issn | 0014-2972 | lld:pubmed |
| pubmed-article:9013082 | pubmed:author | pubmed-author:WalterMM | lld:pubmed |
| pubmed-article:9013082 | pubmed:author | pubmed-author:SchlüterHH | lld:pubmed |
| pubmed-article:9013082 | pubmed:author | pubmed-author:AssmannGG | lld:pubmed |
| pubmed-article:9013082 | pubmed:author | pubmed-author:ZidekWW | lld:pubmed |
| pubmed-article:9013082 | pubmed:author | pubmed-author:TepelMM | lld:pubmed |
| pubmed-article:9013082 | pubmed:author | pubmed-author:HeidenreichSS | lld:pubmed |
| pubmed-article:9013082 | pubmed:author | pubmed-author:NoferJ RJR | lld:pubmed |
| pubmed-article:9013082 | pubmed:author | pubmed-author:BeinlichAA | lld:pubmed |
| pubmed-article:9013082 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9013082 | pubmed:volume | 26 | lld:pubmed |
| pubmed-article:9013082 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9013082 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9013082 | pubmed:pagination | 1077-84 | lld:pubmed |
| pubmed-article:9013082 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:9013082 | pubmed:meshHeading | pubmed-meshheading:9013082-... | lld:pubmed |
| pubmed-article:9013082 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:9013082 | pubmed:articleTitle | Diadenosine polyphosphates induce transplasma membrane calcium influx in cultured glomerular mesangial cells. | lld:pubmed |
| pubmed-article:9013082 | pubmed:affiliation | Marienhospital Herne, Ruhr-Universität-Bochum, Germany. | lld:pubmed |
| pubmed-article:9013082 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9013082 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9013082 | lld:pubmed |
