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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1997-2-13
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pubmed:abstractText |
Glaucoma is the third-leading cause of blindness in the world, affecting >13.5 million people. Adult-onset primary open-angle glaucoma (POAG) is the most common form of glaucoma in the United States. We present a family in which adult-onset POAG is inherited as an autosomal dominant trait. Twelve affected family members were identified from 44 at-risk individuals. The disease-causing gene was mapped to chromosome 3q21-24, with analysis of recombinant haplotypes suggesting a total inclusion region of 11.1 cM between markers D3S3637 and D3S1744. This is the first report of mapping of an adult-onset POAG gene to chromosome 3q, gene symbol GLC1C.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/9012402-13268535,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9012402-1358798,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9012402-1429570,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9012402-1478664,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9012402-1611907,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9012402-1685141,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9012402-1769658,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9012402-2173154,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9012402-2521237,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9012402-3434238,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9012402-4406856,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9012402-5931261,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9012402-5954089,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9012402-6067496,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9012402-6585826,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9012402-6969603,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9012402-7387958,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9012402-7447769,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9012402-7493020,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9012402-7545953,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9012402-7649543,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9012402-7713099,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9012402-7762566,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9012402-7919381,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9012402-7987708,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9012402-8056435,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9012402-8060926,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9012402-8088822,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9012402-8091227,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9012402-8102558,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9012402-8198155,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9012402-8252048,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9012402-8279471,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9012402-8285897,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9012402-8317490,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9012402-8373596,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9012402-849183,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9012402-8513321,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9012402-8595403,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9012402-8595404,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9012402-8600387,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9012402-8637692,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9012402-8812425,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9012402-9012399
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0002-9297
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
60
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
296-304
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:9012402-Adult,
pubmed-meshheading:9012402-Aged,
pubmed-meshheading:9012402-Chromosome Mapping,
pubmed-meshheading:9012402-Chromosomes, Human, Pair 3,
pubmed-meshheading:9012402-Female,
pubmed-meshheading:9012402-Genes, Dominant,
pubmed-meshheading:9012402-Genetic Linkage,
pubmed-meshheading:9012402-Glaucoma, Open-Angle,
pubmed-meshheading:9012402-Humans,
pubmed-meshheading:9012402-Male,
pubmed-meshheading:9012402-Microsatellite Repeats,
pubmed-meshheading:9012402-Middle Aged,
pubmed-meshheading:9012402-Pedigree
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pubmed:year |
1997
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pubmed:articleTitle |
Mapping a gene for adult-onset primary open-angle glaucoma to chromosome 3q.
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pubmed:affiliation |
Department of Ophthalmology, Oregon Health Sciences University, Portland 97201-4197, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Case Reports,
Research Support, Non-U.S. Gov't
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