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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5301
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pubmed:dateCreated |
1997-2-24
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pubmed:abstractText |
Calcium signals were recorded from glial cells in acutely isolated rat retina to determine whether Ca2+ waves occur in glial cells of intact central nervous system tissue. Chemical (adenosine triphosphate), electrical, and mechanical stimulation of astrocytes initiated increases in the intracellular concentration of Ca2+ that propagated at approximately 23 micrometers per second through astrocytes and Müller cells as intercellular waves. The Ca2+ waves persisted in the absence of extracellular Ca2+ but were largely abolished by thapsigargin and intracellular heparin, indicating that Ca2+ was released from intracellular stores. The waves did not evoke changes in cell membrane potential but traveled synchronously in astrocytes and Müller cells, suggesting a functional linkage between these two types of glial cells. Such glial Ca2+ waves may constitute an extraneuronal signaling pathway in the central nervous system.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/9012354-1320034,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9012354-1351732,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9012354-1629725,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9012354-1647876,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9012354-1675864,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9012354-1967852,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9012354-2138778,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9012354-3136153,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9012354-3582510,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9012354-3724960,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9012354-7544323,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9012354-7561845,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9012354-7621532,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9012354-7643199,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9012354-7643223,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9012354-7911978,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9012354-7927645,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9012354-8093125,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9012354-8094375,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9012354-8134839,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9012354-8244537,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9012354-8537822,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9012354-8843598
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0036-8075
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
7
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pubmed:volume |
275
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
844-7
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:9012354-Adenosine Triphosphate,
pubmed-meshheading:9012354-Animals,
pubmed-meshheading:9012354-Astrocytes,
pubmed-meshheading:9012354-Calcium,
pubmed-meshheading:9012354-Calcium Channels,
pubmed-meshheading:9012354-Electric Stimulation,
pubmed-meshheading:9012354-Heparin,
pubmed-meshheading:9012354-Inositol 1,4,5-Trisphosphate Receptors,
pubmed-meshheading:9012354-Kinetics,
pubmed-meshheading:9012354-Membrane Potentials,
pubmed-meshheading:9012354-Neuroglia,
pubmed-meshheading:9012354-Physical Stimulation,
pubmed-meshheading:9012354-Rats,
pubmed-meshheading:9012354-Receptors, Cytoplasmic and Nuclear,
pubmed-meshheading:9012354-Retina,
pubmed-meshheading:9012354-Signal Transduction,
pubmed-meshheading:9012354-Stimulation, Chemical,
pubmed-meshheading:9012354-Thapsigargin
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pubmed:year |
1997
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pubmed:articleTitle |
Calcium waves in retinal glial cells.
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pubmed:affiliation |
Department of Physiology, University of Minnesota, 435 Delaware Street, SE, Minneapolis, MN 55455, USA.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, U.S. Gov't, P.H.S.
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