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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
12
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pubmed:dateCreated |
1997-2-27
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pubmed:abstractText |
Recent experimental work has shown that the mitogen-activated protein (MAP) kinase cascade can convert graded inputs into switch-like outputs. The cascade could therefore filter out noise (signals of insufficient magnitude or duration) and still respond decisively to supra-threshold stimuli. Here, we explore the biochemical mechanisms likely to be at the root of this behavior.
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pubmed:grant | |
pubmed:commentsCorrections | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Dec
|
pubmed:issn |
0968-0004
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
21
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
|
pubmed:pagination |
460-6
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:9009826-Animals,
pubmed-meshheading:9009826-Enzyme Inhibitors,
pubmed-meshheading:9009826-Humans,
pubmed-meshheading:9009826-Models, Biological,
pubmed-meshheading:9009826-Phosphorylation,
pubmed-meshheading:9009826-Protein Kinases,
pubmed-meshheading:9009826-Signal Transduction,
pubmed-meshheading:9009826-Xenopus
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pubmed:year |
1996
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pubmed:articleTitle |
Tripping the switch fantastic: how a protein kinase cascade can convert graded inputs into switch-like outputs.
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pubmed:affiliation |
Department of Molecular Pharmacology, Stanford University School of Medicine, CA 94305-5332, USA. ferrell@cmgm.stanford.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Review,
Research Support, Non-U.S. Gov't
|