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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
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pubmed:dateCreated |
1997-3-11
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pubmed:abstractText |
To quantify the renal excretion of angiotensin II (AII) in birds, synthetic AII was intravenously infused into conscious Pekin ducks at rates of 5, 15 and 45 ng/kg/min for 30 min and the relationships between plasma and urine AII concentrations were monitored by radioimmunoassay. The infusions of AII produced dose-dependent elevations in the plasma concentrations of the hormone, however, urinary concentrations and excretion rates did not change significantly from the basal values of 11.6 +/- 1.2 pg/ml and 4.3 +/- 1.0 pg/min, respectively. The metabolic clearance rate of AII remained constant at each infusion dose (approximately 120 ml/min/kg). The urinary clearance rates (< 0.3 ml/min/kg) indicated that the fraction of AII cleared from the blood via the urine was less than 0.2%. Clearly, excretion of intact AII via this route is not a quantitatively important means of elimination for this hormone in birds.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1096-4940
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
115
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
335-9
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9008356-Analysis of Variance,
pubmed-meshheading:9008356-Angiotensin II,
pubmed-meshheading:9008356-Animals,
pubmed-meshheading:9008356-Dose-Response Relationship, Drug,
pubmed-meshheading:9008356-Ducks,
pubmed-meshheading:9008356-Female,
pubmed-meshheading:9008356-Kidney,
pubmed-meshheading:9008356-Male,
pubmed-meshheading:9008356-Metabolic Clearance Rate,
pubmed-meshheading:9008356-Radioimmunoassay
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pubmed:year |
1996
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pubmed:articleTitle |
Urinary clearance of angiotensin II in Pekin ducks.
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pubmed:affiliation |
Department of Physiology, University of the Witwatersrand, Johannesburg, South Africa.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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