Linked Life Data

9007517

Source:http://linkedlifedata.com/resource/pubmed/id/9007517

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1997-5-15
pubmed:abstractText
The presence of functional endothelin ETB receptors was investigated in rat isolated mesenteric resistance arteries. Neither endothelin-3 (0.1-100 nM) nor the endothelin ETB selective agonists sarafotoxin S6c and BQ 3020 (both 1-100 nM) induced any measurable hyperpolarization or relaxation in stimulated (alpha 1-adrenoceptor agonist; phenylephrine) or unstimulated arteries. In both cases, the subsequent addition of acetylcholine (1 microM) hyperpolarized the membrane potential by 10-20 mV and totally reversed any contraction which was present. These results indicate that the endothelin ETB-mediated vasodilatation observed in the intact mesenteric bed does not reflect hyperpolarization of smooth muscle cells in resistance arteries arising from the mesenteric artery.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0014-2999
pubmed:author
pubmed:issnType
Print
pubmed:day
27
pubmed:volume
318
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
89-92
pubmed:dateRevised
2009-9-29
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
Lack of endothelin ETB receptor-mediated smooth muscle hyperpolarization in rat mesenteric resistance arteries.
pubmed:affiliation
Department of Pharmacology, University of Bristol, University Walk, UK.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't