Linked Life Data

9007160

Source:http://linkedlifedata.com/resource/pubmed/id/9007160

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
1997-2-19
pubmed:abstractText
The cellular response of peripheral blood mononuclear cells (PBMC) from patients with B-cell chronic lymphocytic leukemia to increasing doses of acyclovir was examined by their capacity to incorporate 3H-TdR, and their response to phytohemagglutinin, concanavalin A and pokeweed mitogen. PBMC from healthy donors served as controls. Acyclovir caused a dose-dependent inhibition of 3H-TdR incorporation and mitogenic response in both leukemic and control cells, the effect on the latter being more pronounced. Although the results suggest that leukemic cells are less vulnerable than the controls, the toxic effect of acyclovir on the cellular immune response should be considered in the treatment of leukemic and other immunosuppressed patients.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0021-2180
pubmed:author
pubmed:issnType
Print
pubmed:volume
32
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1228-31
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
The effect of acyclovir on the proliferative capacity of mononuclear cells from patients with chronic lymphocytic leukemia.
pubmed:affiliation
Research Laboratory, Rabin Medical Center, Petah Tikva, Israel.
pubmed:publicationType
Journal Article, Clinical Trial, Controlled Clinical Trial