Linked Life Data

9006802

Source:http://linkedlifedata.com/resource/pubmed/id/9006802

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1997-4-8
pubmed:abstractText
To investigate whether there were associations between the free fatty acid (FFA) response during a fat tolerance test and changes in concentrations of triglyceride-rich lipoproteins 57 healthy Caucasian men between 57 and 70 years of age underwent a fat tolerance test lasting 8 h. FFA concentrations initially decreased from 0.75 +/- 0.03 to 0.64 +/- 0.03 mmol/l at 2 h and thereafter increased to 1.2 +/- 0.04 mmol/l at 8 h. Maximum FFA concentration was the only significant determinant of 8 h triglyceride-rich lipoprotein (TGRLP) concentrations (pooled chylomicron and VLDL fractions d < 1.006) (TGRLP-TG r = 0.33, P = 0.012; TGRLP apo B r = 0.37, P = 0.004; TGRLP cholesterol r = 0.38, P = 0.004). The strength of the association between FFA and TGRLP was affected by the apo B signal peptide genotype. Only in individuals who were homozygous for the 27 amino acid (SP27 or I) allele of the apo B signal peptide were there significant associations between maximum FFA concentration quartile and 8 h TGRLP concentration (P value for linear trend = 0.025). In this genotype group there were lower HDL cholesterol concentrations (1.16 mmol/l compared to 1.38 mmol/l in subjects either heterozygous or homozygous for the SP24 [D] allele; P = 0.005) and there was a trend toward increased 8 h TGRLP concentrations. We propose that the association between post-prandial FFA concentrations and post-prandial TGRLP concentrations in individuals who are homozygous for the SP27 allele may be linked to the increased prevalence of ischemic heart disease (IHD) in this genotypic group.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0021-9150
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
127
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
35-42
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:9006802-Aged, pubmed-meshheading:9006802-Apolipoproteins B, pubmed-meshheading:9006802-Biological Transport, pubmed-meshheading:9006802-Chylomicrons, pubmed-meshheading:9006802-DNA, pubmed-meshheading:9006802-Fatty Acids, Nonesterified, pubmed-meshheading:9006802-Gene Deletion, pubmed-meshheading:9006802-Genotype, pubmed-meshheading:9006802-Humans, pubmed-meshheading:9006802-Immunoradiometric Assay, pubmed-meshheading:9006802-Lipoproteins, VLDL, pubmed-meshheading:9006802-Male, pubmed-meshheading:9006802-Middle Aged, pubmed-meshheading:9006802-Myocardial Ischemia, pubmed-meshheading:9006802-Polymerase Chain Reaction, pubmed-meshheading:9006802-Polymorphism, Genetic, pubmed-meshheading:9006802-Postprandial Period, pubmed-meshheading:9006802-Prevalence, pubmed-meshheading:9006802-Protein Sorting Signals, pubmed-meshheading:9006802-Reference Values, pubmed-meshheading:9006802-Triglycerides, pubmed-meshheading:9006802-Ultracentrifugation
pubmed:year
1996
pubmed:articleTitle
The association between free fatty acid concentrations and triglyceride-rich lipoproteins in the post-prandial state is altered by a common deletion polymorphism of the apo B signal peptide.
pubmed:affiliation
University Department of Clinical Biochemistry, Addenbrookes Hospital, Cambridge, UK. cdtb@mole.bio.cam.ac.uk
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't