| pubmed-article:900634 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:900634 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:900634 | lifeskim:mentions | umls-concept:C0034067 | lld:lifeskim |
| pubmed-article:900634 | lifeskim:mentions | umls-concept:C0064833 | lld:lifeskim |
| pubmed-article:900634 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:900634 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:900634 | pubmed:dateCreated | 1977-10-20 | lld:pubmed |
| pubmed-article:900634 | pubmed:abstractText | Purified human leukocyte elastase was injected into the tracheas of 46 hamsters. Thirteen animals died spontaneously within 1 week, with extensive lung hemorrhage. The elastin content of the lungs was only slightly less than control values 3 hours after injection. At 2 months, the lungs of the remaining animals showed mild, patchy emphysema and morphometric changes consistent with emphysema. These results contrasted with the effects of a similar elastolytic dose of pancreatic elastase administered to 26 other hamsters in that only one animal died spontaneously, the lung elastin content 3 hours after injection was substantially decreased, and severe emphysema was present 2 months later. Leukocyte elastase appears to be capable of causing emphysema; but unlike pancreatic elastase, leukocyte elastase produces emphysema that is mild, even at a dose sufficient to produce intense lung hemorrhage and a high mortality. | lld:pubmed |
| pubmed-article:900634 | pubmed:language | eng | lld:pubmed |
| pubmed-article:900634 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:900634 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:900634 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:900634 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:900634 | pubmed:issn | 0003-0805 | lld:pubmed |
| pubmed-article:900634 | pubmed:author | pubmed-author:StarcherB CBC | lld:pubmed |
| pubmed-article:900634 | pubmed:author | pubmed-author:KEMPA MAM | lld:pubmed |
| pubmed-article:900634 | pubmed:author | pubmed-author:OhlssonKK | lld:pubmed |
| pubmed-article:900634 | pubmed:author | pubmed-author:TegnerHH | lld:pubmed |
| pubmed-article:900634 | pubmed:author | pubmed-author:PierceJ AJA | lld:pubmed |
| pubmed-article:900634 | pubmed:author | pubmed-author:SeniorR MRM | lld:pubmed |
| pubmed-article:900634 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:900634 | pubmed:volume | 116 | lld:pubmed |
| pubmed-article:900634 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:900634 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:900634 | pubmed:pagination | 469-75 | lld:pubmed |
| pubmed-article:900634 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:900634 | pubmed:year | 1977 | lld:pubmed |
| pubmed-article:900634 | pubmed:articleTitle | The induction of pulmonary emphysema with human leukocyte elastase. | lld:pubmed |
| pubmed-article:900634 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:900634 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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