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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
1977-10-20
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pubmed:abstractText |
Purified human leukocyte elastase was injected into the tracheas of 46 hamsters. Thirteen animals died spontaneously within 1 week, with extensive lung hemorrhage. The elastin content of the lungs was only slightly less than control values 3 hours after injection. At 2 months, the lungs of the remaining animals showed mild, patchy emphysema and morphometric changes consistent with emphysema. These results contrasted with the effects of a similar elastolytic dose of pancreatic elastase administered to 26 other hamsters in that only one animal died spontaneously, the lung elastin content 3 hours after injection was substantially decreased, and severe emphysema was present 2 months later. Leukocyte elastase appears to be capable of causing emphysema; but unlike pancreatic elastase, leukocyte elastase produces emphysema that is mild, even at a dose sufficient to produce intense lung hemorrhage and a high mortality.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0003-0805
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
116
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
469-75
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:900634-Animals,
pubmed-meshheading:900634-Cricetinae,
pubmed-meshheading:900634-Elastin,
pubmed-meshheading:900634-Humans,
pubmed-meshheading:900634-Leukocytes,
pubmed-meshheading:900634-Lung,
pubmed-meshheading:900634-Pancreatic Elastase,
pubmed-meshheading:900634-Pulmonary Emphysema
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pubmed:year |
1977
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pubmed:articleTitle |
The induction of pulmonary emphysema with human leukocyte elastase.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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