Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1997-2-7
pubmed:abstractText
Neutrophils (PMNs) and their toxic contents can injure glomeruli, but to date their fate in glomerulonephritis has been unknown. We studied glomerulonephritis induced in rats by formation of concanavalin A (Con A)/anti-Con A immune complexes on glomerular endothelial cells. PMN infiltration, which was almost exclusively confined to the lumen of glomerular capillaries, was transient, peaking at 4 hours, with only 9.0 +/- 4.1% (mean +/- SEM) of the maximum remaining at 24 hours. There was clear evidence of PMN apoptosis leading to phagocytosis in situ by intraluminal macrophages. However, the kinetics of leukocyte infiltration and PMN apoptosis, the preferential location at 24 hours of apoptotic PMNs within occluded capillary loops, and tracking of radiolabeled PMNs all indicated that in situ phagocytic clearance after apoptosis was the fate of a minority of PMNs, amounting to no more than one-fifth of the peak infiltrating load. Instead, the majority of infiltrating PMNs (72.9 +/- 3.1%) had emigrated from inflamed glomeruli by 24 hours, apparently returning to the circulation. We conclude that PMN emigration from inflamed glomeruli is a hitherto unrecognized mechanism for regulation of PMN-mediated glomerular injury.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/9006338-1333549, http://linkedlifedata.com/resource/pubmed/commentcorrection/9006338-1623522, http://linkedlifedata.com/resource/pubmed/commentcorrection/9006338-1679867, http://linkedlifedata.com/resource/pubmed/commentcorrection/9006338-1688647, http://linkedlifedata.com/resource/pubmed/commentcorrection/9006338-1968315, http://linkedlifedata.com/resource/pubmed/commentcorrection/9006338-2051718, http://linkedlifedata.com/resource/pubmed/commentcorrection/9006338-2445883, http://linkedlifedata.com/resource/pubmed/commentcorrection/9006338-2533296, http://linkedlifedata.com/resource/pubmed/commentcorrection/9006338-2746139, http://linkedlifedata.com/resource/pubmed/commentcorrection/9006338-2822992, http://linkedlifedata.com/resource/pubmed/commentcorrection/9006338-2921324, http://linkedlifedata.com/resource/pubmed/commentcorrection/9006338-3049904, http://linkedlifedata.com/resource/pubmed/commentcorrection/9006338-3404972, http://linkedlifedata.com/resource/pubmed/commentcorrection/9006338-3546374, http://linkedlifedata.com/resource/pubmed/commentcorrection/9006338-3605849, http://linkedlifedata.com/resource/pubmed/commentcorrection/9006338-3882559, http://linkedlifedata.com/resource/pubmed/commentcorrection/9006338-4236490, http://linkedlifedata.com/resource/pubmed/commentcorrection/9006338-4262347, http://linkedlifedata.com/resource/pubmed/commentcorrection/9006338-6807336, http://linkedlifedata.com/resource/pubmed/commentcorrection/9006338-7066631, http://linkedlifedata.com/resource/pubmed/commentcorrection/9006338-7400310, http://linkedlifedata.com/resource/pubmed/commentcorrection/9006338-7638810, http://linkedlifedata.com/resource/pubmed/commentcorrection/9006338-765016, http://linkedlifedata.com/resource/pubmed/commentcorrection/9006338-7865221, http://linkedlifedata.com/resource/pubmed/commentcorrection/9006338-7962557, http://linkedlifedata.com/resource/pubmed/commentcorrection/9006338-8076517, http://linkedlifedata.com/resource/pubmed/commentcorrection/9006338-8388425, http://linkedlifedata.com/resource/pubmed/commentcorrection/9006338-8485918
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0002-9440
pubmed:author
pubmed:issnType
Print
pubmed:volume
150
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
223-34
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
Neutrophil fate in experimental glomerular capillary injury in the rat. Emigration exceeds in situ clearance by apoptosis.
pubmed:affiliation
Department of Medicine, University Hospital, Nottingham, United Kingdom.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't