|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0008976,
umls-concept:C0018943,
umls-concept:C0034656,
umls-concept:C0055598,
umls-concept:C0072146,
umls-concept:C0086409,
umls-concept:C0087111,
umls-concept:C0200627,
umls-concept:C0376545,
umls-concept:C0443252,
umls-concept:C1274040,
umls-concept:C1332225,
umls-concept:C1413947,
umls-concept:C1521808,
umls-concept:C2603343
|
|
pubmed:issue |
5
|
|
pubmed:dateCreated |
1997-2-14
|
|
pubmed:abstractText |
From May 1985 to May 1989, 175 patients with previously untreated aggressive non-Hodgkin's lymphoma were randomized to receive CHOP or ProMACE-CytaBOM. Eligibility criteria included follicular large-cell diffuse small cleaved-cell, diffuse mixed, diffuse large-cell and immunoblastic lymphoma with an Ann Arbor stage II, III or IV. One hundred and forty-eight patients were evaluable. There were no significant differences between the 2 treatments in response rate (83.5% [57.5% CR] for CHOP vs. 88% [62% CR] for ProMACE-CytaBOM), time to treatment failure (29% vs. 31% at 5 yr), or overall survival (42% in both groups at 5 yr). Furthermore, there were no significant differences between the 2 regimens when response rates and outcome were analyzed for different prognostic subgroups. Toxicity was not significantly different between the 2 regimens, although only 1 patient died as result of treatment-related toxicity in the CHOP arm compared to 6 patient in the ProMACE-CytaBOM group (p = 0.126). In conclusion, in this study ProMACE-CytaBOM has not proved to be superior to CHOP in aggressive lymphomas. This trial gives support to the notion that CHOP still is the standard chemotherapy for aggressive lymphomas, and that new treatment approaches for these lymphomas should be compared to CHOP.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Nov
|
|
pubmed:issn |
0902-4441
|
|
pubmed:author |
pubmed-author:AlcaláAA,
pubmed-author:BladéJJ,
pubmed-author:EstapéJJ,
pubmed-author:FauraM VMV,
pubmed-author:FontanillasMM,
pubmed-author:García-CondeJJ,
pubmed-author:Hernández-NietoLL,
pubmed-author:López-GuillermoAA,
pubmed-author:LlorenteAA,
pubmed-author:MaldonadoJJ,
pubmed-author:MontserratEE,
pubmed-author:ViñolasNN,
pubmed-author:ZubizarretaAA
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
57
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
377-83
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:9003479-Adult,
pubmed-meshheading:9003479-Aged,
pubmed-meshheading:9003479-Aged, 80 and over,
pubmed-meshheading:9003479-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:9003479-Bleomycin,
pubmed-meshheading:9003479-Cyclophosphamide,
pubmed-meshheading:9003479-Cytarabine,
pubmed-meshheading:9003479-Doxorubicin,
pubmed-meshheading:9003479-Etoposide,
pubmed-meshheading:9003479-Female,
pubmed-meshheading:9003479-Humans,
pubmed-meshheading:9003479-Lymphoma, Non-Hodgkin,
pubmed-meshheading:9003479-Male,
pubmed-meshheading:9003479-Methotrexate,
pubmed-meshheading:9003479-Middle Aged,
pubmed-meshheading:9003479-Prednisone,
pubmed-meshheading:9003479-Treatment Outcome,
pubmed-meshheading:9003479-Vincristine
|
|
pubmed:year |
1996
|
|
pubmed:articleTitle |
CHOP vs. ProMACE-CytaBOM in the treatment of aggressive non-Hodgkin's lymphomas: long-term results of a multicenter randomized trial.(PETHEMA: Spanish Cooperative Group for the Study of Hematological Malignancies Treatment, Spanish Society of Hematology).
|
|
pubmed:affiliation |
Department of Hematology, University of Barcelona, Spain.
|
|
pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't,
Multicenter Study
|
