rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1997-2-24
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pubmed:databankReference |
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pubmed:abstractText |
Rat liver phosphoribosylpyrophosphate synthetase is a complex aggregate of 34-kDa catalytic subunits (PRS I and II) and 39- and 41-kDa associated proteins (PAP39 and 41). When the rat cDNA encoding PAP41 was isolated, the deduced protein sequence was seen to contain 369 amino acids with a calculated molecular mass of 41130. PAP41 has a 79 and 49% identity with PAP39 and PRSs, respectively. When conservative substitutions are included, PAP41 and the three other components have a 66% homology. PAP41 shares some common features with PAP39 and the two proteins form the PAP subfamily. The mRNA of PAP41 is present in all rat tissues we examined.
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pubmed:language |
eng
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pubmed:journal |
|
pubmed:citationSubset |
IM
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pubmed:chemical |
|
pubmed:status |
MEDLINE
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pubmed:month |
Jan
|
pubmed:issn |
0006-3002
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pubmed:author |
|
pubmed:issnType |
Print
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pubmed:day |
3
|
pubmed:volume |
1350
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
6-10
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9003449-Amino Acid Sequence,
pubmed-meshheading:9003449-Animals,
pubmed-meshheading:9003449-Base Sequence,
pubmed-meshheading:9003449-DNA, Complementary,
pubmed-meshheading:9003449-Liver,
pubmed-meshheading:9003449-Macromolecular Substances,
pubmed-meshheading:9003449-Male,
pubmed-meshheading:9003449-Molecular Sequence Data,
pubmed-meshheading:9003449-Molecular Weight,
pubmed-meshheading:9003449-Organ Specificity,
pubmed-meshheading:9003449-Peptide Fragments,
pubmed-meshheading:9003449-Protein Biosynthesis,
pubmed-meshheading:9003449-Proteins,
pubmed-meshheading:9003449-Rats,
pubmed-meshheading:9003449-Rats, Sprague-Dawley,
pubmed-meshheading:9003449-Sequence Homology, Amino Acid,
pubmed-meshheading:9003449-Transcription, Genetic
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pubmed:year |
1997
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pubmed:articleTitle |
Cloning and sequencing of rat cDNA for the 41-kDa phosphoribosylpyrophosphate synthetase-associated protein has a high homology to the catalytic subunits and the 39-kDa associated protein.
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pubmed:affiliation |
Department of Biochemistry, Chiba University School of Medicine, Japan. cum121j@med.m.chiba-u.ac.jp
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|