Linked Life Data

9001579

Source:http://linkedlifedata.com/resource/pubmed/id/9001579

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1997-2-12
pubmed:abstractText
Three functional elements are required for the stable transmission of eukaryotic chromosomes: replication origins, centromeres and telomeres. In the yeast Saccharomyces cerivisiae the DNA sequences defining each of these elements are known. The simplest and most widely conserved of these sequences is that of the telomere. As the name implies, the telomere is the end of a linear eukaryotic chromosome. Two of the main functions of the telomere are to prevent DNA loss as a consequence of replication and to prevent interactions with other chromosomal ends. Thus, telomeres play a major role in maintaining chromosome stability and consequently they have been considered as likely to be involved in some aspects of chromosomal aberration formation. The involvement of telomeric DNA sequences in stabilizing normal and broken chromosome ends, in "hot spots' for aberration formation and in delayed chromosomal instability will be reviewed here drawing on material presented at the Workshop and the published literature.
pubmed:keyword
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0027-5107
pubmed:author
pubmed:issnType
Print
pubmed:volume
366
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
129-35
pubmed:dateRevised
2005-11-16
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
The involvement of telomeric sequences in chromosomal aberrations.
pubmed:affiliation
Biomedical Effects Department, National Radiological Protection Board, Didcot, Oxon, UK.
pubmed:publicationType
Journal Article, Review