Linked Life Data

9001143

Source:http://linkedlifedata.com/resource/pubmed/id/9001143

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1997-4-3
pubmed:abstractText
The 2H DQF NMR spectra of deuterated water molecules were measured for the first time in in vivo rat brain. The observation of the DQF signal indicates that there is a water population that exhibits anisotropic motion. The characteristics of the DQF spectra premortem and postmortem are very similar (lineshape and relaxation times). In the 1st h there is a 10-15% decrease in the signal intensity of the DQF spectra followed by a gradual but a much slower decrease in the DQF signal intensity that reaches 65-70% of its initial value after only 12 h. When the brains were kept at 4 degrees C, a 40% decrease in the DQ signal intensity was observed only after 7 days. Mechanical chopping of the brain tissues causes an immediate loss of more that 97% of the DQ signals. The slow, temperature-sensitive decay of the signal, and its sensitivity to mechanical treatment point out that these signals originate from water molecules that interact with structural components in the brain. The characteristics of the DQF spectra depend on the amount of bulk water as exemplified by increased residual quadrupolar interaction and relaxation rates obtained when dehydrating the brain tissue.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0740-3194
pubmed:author
pubmed:issnType
Print
pubmed:volume
37
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
197-203
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
In vivo observation of anisotropic motion of brain water using 2H double quantum filtered NMR spectroscopy.
pubmed:affiliation
School of Chemistry, The Sackler Faculty of Exact Sciences, Tel Aviv University, Ramat Aviv, Israel.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't