Linked Life Data

9000682

Source:http://linkedlifedata.com/resource/pubmed/id/9000682

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1997-2-13
pubmed:abstractText
Female Wistar rats mated with male Wistar rats were given 15 mg/kg cyclosporine (CsA) per day during pregnancy (to 21 days after coitus). Other rats were mated and were used as controls. The pups born from treated mothers were fed by control mothers and those born from control mothers were fed by treated mothers. The newborn rats showed temporary defects in the development of some hemopoietic organs (the thymus, spleen, liver, and bone marrow). There was no difference in the structure of the organs studied between the litters fed by control mothers and those fed by treated mothers. The structure of the hemopoietic organs resembled those of the controls 30 days after birth. Our findings show that the delay in the development of the organs studied is due to the transplacental passage of CsA and suggest that it could be due to CsA interference in the maternal immune response to specific embryonic antigens.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0041-1337
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
63
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
164-7
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
Cyclosporine and pregnancy in the rat.
pubmed:affiliation
Department of Biomedical Sciences and Biotechnology, University of Brescia, Italy.
pubmed:publicationType
Journal Article