Linked Life Data

9000553

Source:http://linkedlifedata.com/resource/pubmed/id/9000553

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1997-2-11
pubmed:abstractText
Familial adenomatous polyposis (FAP), due to germ-line mutation of the adenomatous polyposis coli (APC) gene, is characterized by development of colorectal adenomas and ultimately colorectal cancer. The usefulness of ornithine decarboxylase (ODC) activity and polyamine levels in normal-appearing colorectal mucosa to stratify risk for colorectal neoplasia by discriminating presymptomatic individuals with germ-line APC mutation (genotype-positive) from genotype-negative family controls was evaluated in 36 at-risk subjects undergoing endoscopic and genetic screening for FAP. ODC activity and levels of putrescine, spermidine, and spermine were significantly higher in presymptomatic genotype-positive patients compared to genotype-negative persons (P = 0.029, <0.001, 0.002, and <0.001, respectively). Moreover, a putrescine level with a cutoff point of 1.5 nmol/mg protein was the most accurate single discriminator of risk status. ODC activity and polyamine levels are significantly elevated in gene carriers of FAP before the development of polyposis, suggesting a role for these compounds in tumorigenesis of FAP. These assays may be useful in evaluating at-risk members of FAP families in which mutation of the APC gene cannot be found.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0008-5472
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
57
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
199-201
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
Ornithine decarboxylase and polyamines in familial adenomatous polyposis.
pubmed:affiliation
Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't