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pubmed:abstractText |
Ribozymes catalyze an important set of chemical transformations in metabolism, and 'engineered' ribozymes have been made that catalyze a variety of additional reactions. The possibility that catalytic DNAs or 'deoxyribozymes' can be made has only recently been addressed. Specifically, it is unclear whether the absence of the 2' hydroxyl renders DNA incapable of exhibiting efficient enzyme-like activity, making it impossible to discover natural or create artificial DNA biocatalysts.
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