Linked Life Data

8998969

Source:http://linkedlifedata.com/resource/pubmed/id/8998969

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1997-1-17
pubmed:abstractText
Prothoracicotropic hormone (PTTH) controls the synthesis of ecdysteroids (molting hormones) by the insect prothoracic gland and thereby plays a critical role in insect growth, molting, and metamorphosis. PTTH has been purified, and cDNA clones obtained, from only one insect, the silkmoth Bombyx mon. Recently, a partial amino acid sequence was obtained for-a putative PTTH from the tobacco hornworm, Manduca sexta, and the data suggested an unexpected homology to a vertebrate retinoid binding protein rather than to the Bombyx PTTH. In this study, a monoclonal antibody against the Bombyx PTTH was added to in vitro assays that assess the ability of partially purified Manduca PTTH to stimulate prothoracic gland ecdysteroid and protein synthesis. The results indicate that Bombyx and Manduca PTTHs are indeed members of the same protein family that have likely diverged in the PTTH receptor-binding region.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0016-6480
pubmed:author
pubmed:issnType
Print
pubmed:volume
102
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
247-54
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
Bombyx and Manduca prothoracicotropic hormones: an immunologic test for relatedness.
pubmed:affiliation
Department of Biology, University of North Carolina 27599-3280, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S.