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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
19
|
| pubmed:dateCreated |
1997-1-23
|
| pubmed:abstractText |
The critical moment of regulation when transition of the cell from the G1 to the S phase takes which is decisive for its division is the so-called R-point (restriction point). The disorder of molecular mechanisms controlling the passage of the cell through this site is an associated manifestation of most tumourous processes. A considerable part of this mechanism is the RB protein, binding transcription factors needed for the activation of genes effective in the S phase. Its binding capacity depends on the extent of phosphorylation and on the activity of the appropriate kinases and their inhibitors.
|
| pubmed:language |
cze
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
0008-7335
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
9
|
| pubmed:volume |
135
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
634-5
|
| pubmed:dateRevised |
2009-11-19
|
| pubmed:meshHeading | |
| pubmed:year |
1996
|
| pubmed:articleTitle |
[Control mechanisms of cell transition from the G1 phase to the S phase--the R point].
|
| pubmed:affiliation |
Danish Cancer Soc., Div. Tumor Biol., Copenhagen.
|
| pubmed:publicationType |
Journal Article,
English Abstract
|