Linked Life Data

8998381

Source:http://linkedlifedata.com/resource/pubmed/id/8998381

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1997-1-17
pubmed:abstractText
Both increased and decreased gestation lengths have been reported following exposures to polychlorinated biphenyl (PCB) mixtures and congeners. Because oscillatory uterine contractions are essential for parturition, we hypothesized that the disparate findings on gestation length may be the result of distinct PCB congener-specific actions on oscillatory uterine contractions. This study examined the acute effects of PCB congeners on isometric contractions of isolated pregnant uteri and the structure-activity relationship for individual congeners. After cumulative exposure to individual PCB congeners (0.5 microM to 150 microM), oscillatory contractions were: 1) not altered by 2,4,5,2',4',5'-hexachlorobiphenyl, 3,4,5,3',4'-pentachlorobiphenyl, or 3,4,3',4'-tetrachlorobiphenyl; 2) significantly inhibited by 4-hydroxy-2',4',6'-trichlorobiphenyl; and 3) markedly increased by 2,4,6-trichlorobiphenyl and 2,4,2',4'-tetrachlorobiphenyl, when compared to solvent controls. The uteri were more sensitive to PCB congeners with ortho-substituted light chlorination than those highly chlorinated, or those interacting with the Ah-receptor.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0890-6238
pubmed:author
pubmed:issnType
Print
pubmed:volume
10
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
21-8
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:articleTitle
Congener-specific effects of PCBs on contractions of pregnant rat uteri.
pubmed:affiliation
Department of Environmental and Industrial Health, University of Michigan, Ann Arbor 48109-2029, USA.
pubmed:publicationType
Journal Article, In Vitro, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't