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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1997-3-11
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pubmed:abstractText |
The effects of four days' treatment with topical Maxitrol (neomycin sulphate 3500 IU/mL, polymyxin-B sulphate 6000 IU/mL with dexamethasone 0.1%) were compared with those of Maxidex (dexamethasone 0.1% alone) in a double-masked study in 111 patients with bacterial blepharitis or conjunctivitis, 95 of whom were evaluable for efficacy. The majority of patients (N = 80) had chronic blepharitis. Maxitrol treatment resulted in a significantly greater reduction (90%) in bacterial counts and bacterial eradication (50%) compared with Maxidex (34% and 17% respectively). Maxitrol treatment also produced a significantly greater reduction in conjunctival discharge than did Maxidex, while the treatments were equally effective in alleviating other ocular signs and symptoms. It was concluded that use of a fixed dose combination steroid-antibiotic product was more effective for bacterial control and therapeutic efficacy in the treatment of chronic blepharitis and conjunctivitis patients than treatment with steroid alone. However, in the long-term treatment of chronic blepharitis the well-known toxic problems of neomycin sulphate have to be taken into account.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1120-6721
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
6
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
361-7
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:8997575-Administration, Topical,
pubmed-meshheading:8997575-Adult,
pubmed-meshheading:8997575-Aged,
pubmed-meshheading:8997575-Aged, 80 and over,
pubmed-meshheading:8997575-Anti-Bacterial Agents,
pubmed-meshheading:8997575-Anti-Inflammatory Agents,
pubmed-meshheading:8997575-Blepharitis,
pubmed-meshheading:8997575-Chronic Disease,
pubmed-meshheading:8997575-Colony Count, Microbial,
pubmed-meshheading:8997575-Conjunctiva,
pubmed-meshheading:8997575-Conjunctivitis, Bacterial,
pubmed-meshheading:8997575-Dexamethasone,
pubmed-meshheading:8997575-Double-Blind Method,
pubmed-meshheading:8997575-Drug Combinations,
pubmed-meshheading:8997575-Eye Infections, Bacterial,
pubmed-meshheading:8997575-Eyelids,
pubmed-meshheading:8997575-Female,
pubmed-meshheading:8997575-Fluprednisolone,
pubmed-meshheading:8997575-Glucocorticoids,
pubmed-meshheading:8997575-Gram-Negative Bacteria,
pubmed-meshheading:8997575-Gram-Positive Bacteria,
pubmed-meshheading:8997575-Humans,
pubmed-meshheading:8997575-Male,
pubmed-meshheading:8997575-Middle Aged,
pubmed-meshheading:8997575-Neomycin,
pubmed-meshheading:8997575-Ophthalmic Solutions,
pubmed-meshheading:8997575-Polymyxin B
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pubmed:articleTitle |
Comparative evaluation of the short-term bactericidal potential of a steroid-antibiotic combination versus steroid in the treatment of chronic bacterial blepharitis and conjunctivitis.
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pubmed:affiliation |
Houston Eye Associates, Texas, USA.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
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