Linked Life Data

8996739

Source:http://linkedlifedata.com/resource/pubmed/id/8996739

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1997-4-25
pubmed:abstractText
Deoxyspergualin (DSG), which was discovered to be an immunosuppressive agent, was examined for its in vivo effect on parasites of rodent malaria. Although the mice that were not treated by DSG had an increased parasite percentage (% parasitemia) until they died, those that were treated with DSG had a decreased parasitemia and finally had 0% parasites. The spleens of infected mice became small by DSG treatment. Parasitemia of mice increased again after DSG treatment was stopped. However, DSG was a polyamine inhibitor. The two other types of polyamine inhibitors used in this study were not effective for decreasing the % parasitemia of Plasmodium berghei. Only DSG was available and the survival time of mice increased. The antiprotozoal effects shown by DSG-even this chemical is an immunosuppressive agent-suggest that there is a relation between the inhibition of the polyamine synthetic pathway or immunosuppression of DSG and the suppressive effect of malarial parasites.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0009-3157
pubmed:author
pubmed:issnType
Print
pubmed:volume
43
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
31-5
pubmed:dateRevised
2009-11-11
pubmed:meshHeading
pubmed:articleTitle
15-Deoxyspergualin, an immunosuppressive agent, used in organ transplantation showed suppressive effects on malarial parasites.
pubmed:affiliation
Suzuka University of Medical Science and Technology, Mie, Japan.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't